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Article ? AI-assigned paper type based on the abstract. Classification may not be perfect — flag errors using the feedback button. Tier 2 ? Original research — experimental, observational, or case-control study. Direct primary evidence. Human Health Effects Sign in to save

Comparison of lung disorders following intratracheal instillation of polystyrene microplastics with different surface functional groups

Journal of Occupational Health 2025
Taisuke Tomonaga, Hidenori Higashi, Hiroto Izumi, Chinatsu Nishida, Kazuma Sato, Yuiko Nakamura, Toshiki Morimoto, Yasuyuki Higashi, Takuma Kojima, Kazuo Sakurai, Kazuhiro Yatera, Yasuo Morimoto

Summary

Intratracheal instillation of polystyrene microplastics with different surface functional groups (plain, carboxylated, aminated) in rats showed low pulmonary toxicity overall, but surface chemistry influenced acute-phase inflammatory responses—suggesting surface functionalization is an important variable in microplastic respiratory toxicity assessment.

Polymers
PS
Body Systems
Respiratory

These results suggest that these polystyrenes do not have high pulmonary toxicity, although there are differences in toxicity due to differences in surface functional groups only in the acute phase.

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