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Maternal Exposure to Polystyrene Nanoplastics During Gestation and Lactation Impaired Skeletal Growth in Progeny Mice by Inhibiting Neutrophil Extracellular Trap Formation
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Maternal exposure to polystyrene nanoplastics during gestation and lactation impaired skeletal growth in progeny mice by inhibiting neutrophil extracellular trap formation
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When pregnant mice were exposed to polystyrene nanoplastics through drinking water, their offspring showed disrupted bone development, including changes in bone density and thinning of growth plates. The nanoplastics interfered with immune cell function and gene regulation in the skeletal system of the young mice. This suggests that maternal nanoplastic exposure during pregnancy could affect fetal bone development, which has implications for human pregnancies given widespread nanoplastic contamination in drinking water.
Prenatal exposure to polystyrene nanoplastics caused testicular development toxicities and relative mechanisms in male offspring mice from embryo to adulthood
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Scientists exposed pregnant mice to nanoplastics (tiny plastic particles found in our environment, blood, and even placentas) and found their male offspring had slowed growth before birth, hit puberty earlier, and had reduced fertility as adults. The nanoplastics appeared to disrupt key genes and cells needed for normal testicle development and hormone production. While this is animal research, it adds to growing evidence that plastic exposure during pregnancy could affect a baby's reproductive development later in life.
Cellular Uptake and Nuclear Accumulation of Polystyrene Nanoplastics in 3T3 Fibroblasts and Hepatocytes of Rattus norvegicus
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Scientists found that tiny plastic particles called nanoplastics can get inside liver and connective tissue cells from rats, and even sneak into the cell's nucleus, where DNA is stored. Cells exposed to these plastics showed signs of stress and damage, including swelling and higher rates of cell death, suggesting these ultra-small plastic particles may be more harmful than previously thought. While this study used animal cells rather than human cells, it raises important questions about what everyday exposure to nanoplastics (found in food packaging, water, and other sources) might mean for our own cellular health.
Maternal Gestational and Lactational Exposure to Polystyrene Nanoplastics Triggers Vascular Injury and Lipid Deposition in Mouse Offspring
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Pregnant and nursing mice were given polystyrene nanoplastics in water. Their offspring showed lower body weight, organ damage, and blood vessel injury including fat buildup in the aorta, with some effects persisting into adulthood. Nanoplastics also caused fat accumulation in lab-grown blood vessel and immune cells.
Maternal exposure to polystyrene nanoplastics causes brain abnormalities in progeny
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Researchers found that maternal exposure to polystyrene nanoplastics caused brain abnormalities in offspring, demonstrating that nanoplastics can cross maternal barriers and affect neurological development in progeny with implications for developmental toxicology.
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