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Original research — experimental, observational, or case-control study. Direct primary evidence.
Environmental Sources
Human Health Effects
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CPT1 deficiency blocks autophagic flux to promote lipid accumulation induced by co-exposure to polystyrene microplastic and cadmium
Frontiers in Pharmacology2025
3 citations
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Citation count from OpenAlex, updated daily. May differ slightly from the publisher's own count.
Score: 58
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0–100 AI score estimating relevance to the microplastics field. Papers below 30 are filtered from public browse.
Jian Sun,
Zhixuan Chen,
Tao Wang,
Hui Zou
Hui Zou
Tao Wang,
Tao Wang,
Tao Wang,
Hui Zou
Tao Wang,
Jian Sun,
Jian Sun,
Huayi Qu,
Huayi Qu,
Huayi Qu,
Tao Wang,
Tao Wang,
Tao Wang,
Huayi Qu,
Huayi Qu,
Huayi Qu,
Huayi Qu,
Huayi Qu,
Huayi Qu,
Tao Wang,
Jian Sun,
Huayi Qu,
Tao Wang,
Tao Wang,
Tao Wang,
Tao Wang,
Tao Wang,
Tao Wang,
Hui Zou
Tao Wang,
Huayi Qu,
Jian Sun,
Jian Sun,
Huayi Qu,
Tao Wang,
Hui Zou
Tao Wang,
Jian Sun,
Tao Wang,
Jianhong Gu,
Yan Yuan,
Tao Wang,
Hui Zou
Hui Zou
Jianhong Gu,
Tao Wang,
Jianhong Gu,
Tao Wang,
Jianhong Gu,
Yan Yuan,
Jianhong Gu,
Yan Yuan,
Hui Zou
Tao Wang,
Yan Yuan,
Yan Yuan,
Yan Yuan,
Hui Zou
Yan Yuan,
Jianchun Bian,
Yan Yuan,
Jianchun Bian,
Yan Yuan,
Yan Yuan,
Jianhong Gu,
Zongping Liu,
Zongping Liu,
Zongping Liu,
Zongping Liu,
Jianhong Gu,
Jianhong Gu,
Yan Yuan,
Zongping Liu,
Zongping Liu,
Zongping Liu,
Zongping Liu,
Hui Zou
Yan Yuan,
Jianchun Bian,
Tao Wang,
Jianchun Bian,
Zongping Liu,
Jianhong Gu,
Hui Zou
Hui Zou
Jianhong Gu,
Hui Zou
Zongping Liu,
Hui Zou
Zongping Liu,
Hui Zou
Jianchun Bian,
Jianchun Bian,
Zongping Liu,
Zongping Liu,
Hui Zou
Summary
Researchers found that combined exposure to polystyrene microplastics and cadmium in mice led to fat accumulation in the liver by blocking a cellular cleanup process called autophagy. The study identified a specific enzyme, CPT1, whose activation could alleviate both the fat buildup and the blocked autophagy pathway. The findings suggest that microplastics may worsen the toxic effects of heavy metals on liver health through shared metabolic pathways.
In conclusion, the concurrent exposure of PS-MPs and Cd resulted in the blockage of hepatic lipid accumulation and autophagic pathway and further aggravated the toxic damage to the liver. Activation of CPT1 could alleviate the PS-MPs and Cd-induced lipid accumulation and autophagy pathway blockage thus reducing liver injury.