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Synergistic neurotoxicity of clothianidin and photoaged microplastics in zebrafish: Implications for neuroendocrine disruption
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This study found that photoaged (sun-weathered) microplastics absorb more of the insecticide clothianidin than fresh plastics, and the combination caused greater nerve damage in zebrafish larvae than either pollutant alone. The results demonstrate how weathered microplastics in the environment can amplify the toxicity of other chemicals they encounter, creating compound exposure risks for aquatic life and potentially for humans through the food chain.
Microplastics (MPs), widely found in aquatic environments, pose a growing threat to environmental and biological health due to their complex interactions with pollutants and microorganisms. This study investigates the adsorption characteristics of clothianidin (CLO) on polystyrene (PS) and photoaged polystyrene (P-PS) and explores the neurotoxic effects of CLO combined with PS/P-PS in larval zebrafish (Danio rerio). Adsorption kinetics and isotherms showed that P-PS exhibited a higher adsorption capacity and faster equilibrium compared to PS, indicating the significant role of photoaging in enhancing CLO adsorption. Exposed to CLO combined with PS/P-PS resulted in reduced locomotor activity, particularly in the P-PS + CLO group, suggesting amplified neurotoxicity due to P-PS. Analysis of the hypothalamic-pituitary-interrenal (HPI) axis revealed elevated levels of adrenocorticotropic hormone (ACTH) and cortisol, along with downregulated expression of stress-related genes in co-exposed zebrafish, indicating disruption of neuroendocrine function. Neurotransmitter analysis showed significant changes in acetylcholine (ACh), dopamine (DA), serotonin (5-HT), and γ-aminobutyric acid (GABA) levels, further confirming the neurotoxic impact of co-exposure. The findings highlight the synergistic neurotoxicity of CLO and photoaged MPs, with potential implications for aquatic ecosystems. This study advances the field of environmental science by addressing critical knowledge gaps in pollutant-microplastic interactions, providing a foundation for developing targeted mitigation strategies and enhancing ecological risk management frameworks.
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Combined neurotoxicity of aged microplastics and thiamethoxam in the early developmental stages of zebrafish (Danio rerio)
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This study found that aged (weathered) microplastics combined with the insecticide thiamethoxam caused worse neurological damage to zebrafish larvae than either pollutant alone. The combined exposure reduced heart rate and movement, disrupted antioxidant defenses, and altered neurotransmitter levels in ways that were synergistic rather than simply additive. This is relevant to human health because both microplastics and pesticides are common in the environment, and their combined effects may pose greater risks than either one individually.
Effects of single and combined exposure of virgin or aged polyethylene microplastics and penthiopyrad on zebrafish (Danio rerio)
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This study found that polyethylene microplastics can increase the toxicity of a common fungicide (penthiopyrad) in zebrafish by helping the chemical build up in their bodies. The combination caused more intestinal damage and disrupted gut bacteria than either pollutant alone. This highlights an important concern: microplastics in the environment can act as carriers for pesticides, potentially amplifying their harmful effects on organisms including those in the human food chain.
Combined toxic effects of polyethylene microplastics and lambda-cyhalothrin on gut of zebrafish (Danio rerio)
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Researchers found that polyethylene microplastics can adsorb the pesticide lambda-cyhalothrin from water and then release it in the guts of zebrafish, worsening its toxic effects. Fish exposed to both microplastics and the pesticide showed greater oxidative stress, immune disruption, and gut microbiome changes than those exposed to the pesticide alone. This demonstrates how microplastics can act as carriers that amplify the toxicity of other environmental pollutants in aquatic organisms consumed by humans.
Effects of micro/nanoplastics combined with three anthropogenic chemicals on larval zebrafish (Danio rerio): study of toxicity, behaviour and assessment of uptake
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Scientists found that tiny plastic particles alone didn't harm baby zebrafish, but when combined with common chemicals found in flame retardants and antidepressants, the plastics made those chemicals more toxic. This suggests that in the real world, where we're exposed to plastic particles and chemicals together, the combination could be more harmful than either one alone—even though this study was in fish, it raises questions about how plastic pollution might amplify chemical risks for humans too.
Toxic effects of polystyrene microplastics on atrazine in zebrafish: Exogenous toxicity and endogenous mechanism
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Researchers found that combining polystyrene microplastics with the common herbicide atrazine was more toxic to zebrafish than either pollutant alone, causing greater liver and gut damage. The combination also degraded water quality by reducing oxygen levels and increasing harmful nitrogen compounds. This is important because microplastics and pesticides frequently co-exist in the environment, meaning their combined effects on aquatic life and food safety may be worse than studies of individual pollutants suggest.
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