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Sex-specific effects of aged polystyrene microplastics on hepatic AMPK pathway activation and lipid droplet accumulation in MAFLD mice

Ecotoxicology and Environmental Safety 2025 2 citations ? Citation count from OpenAlex, updated daily. May differ slightly from the publisher's own count. Score: 58 ? 0–100 AI score estimating relevance to the microplastics field. Papers below 30 are filtered from public browse.

Di Wu, Qing Wang Qing Wang Qing Wang Xiaona Yang, Qing Wang Qing Wang Di Wu, Di Wu, Di Wu, Qing Wang Di Wu, Di Wu, Di Wu, Qing Wang Xiaona Yang, Qing Wang Xiaona Yang, Qing Wang Qing Wang Qing Wang Qing Wang Chuan Chen, Chuan Chen, Xiaona Yang, Di Wu, Di Wu, Xiaona Yang, Qing Wang Ying Xing, Ying Xing, Qing Wang Qing Wang Di Wu, Di Wu, Di Wu, Di Wu, Di Wu, Qing Wang Di Wu, Di Wu, Qing Wang Di Wu, Qing Wang Qing Wang Natasha Chitakwa, Qing Wang Di Wu, Natasha Chitakwa, Di Wu, Qing Wang Di Wu, Jing Jiang, Jing Jiang, Qing Wang Qing Wang Qing Wang Qing Wang Qing Wang Qing Wang Qing Wang Di Wu, Di Wu, Hongcheng Wei, Qing Wang Qing Wang Qing Wang Qing Wang Xiaona Yang, Hongcheng Wei, Hongcheng Wei, Xinliang Ding, Xinliang Ding, Qing Wang Qing Wang Qing Wang Qing Wang Qing Wang Qing Wang Qing Wang Qing Wang Qing Wang Di Wu, Qing Wang Qing Wang Qing Wang Qing Wang Qing Wang Qing Wang Qing Wang Qing Wang Chuan Chen, Qing Wang Qing Wang

Summary

Researchers examined how aged polystyrene microplastics affect liver fat metabolism differently in male and female mice with fatty liver disease. They found that while both sexes showed increased inflammation and oxidative stress, only female mice experienced a reduction in liver fat accumulation, potentially linked to estrogen-related metabolic pathways. The study reveals important sex-specific differences in how microplastics interact with metabolic conditions, suggesting that health effects may vary between males and females.

Polymers

Body Systems

Hepatic Immune

Models

Mouse

Microplastics (MPs) are environmental pollutants attracting widespread attention due to their environmental omnipresence and potential health effects. MPs undergo ageing in the environment and our previous research found that aged Polystyrene microplastics (PS-MPs) affected lipid metabolism in healthy female mice, but not males. In this study, we examined the effects of aged PS-MP exposure on lipid metabolism in mice with Metabolic Associated Fatty Liver Disease (MAFLD). 14 female and 14 male mice were furnished with a high-fat diet (HFD) for eight weeks to create MAFLD model mice. They were then orally administered aged PS-MPs for four weeks, and changes in the AMP-activated protein kinase signalling pathway were examined in order to determine PS-MP's effect on hepatic metabolism. The outcomes showed that though serum estradiol, inflammatory gene expression and ROS levels increased significantly in both male and female HFD-aged PS-MP groups, hepatic steatosis was attenuated only in the female group. Furthermore, serum ERα, ERβ, AMPKα, acetyl-CoA carboxylase, sterol regulatory element binding protein-1c, and Fas expressions were significantly increased in the MAFLD mice groups compared to the control group. Combining serum E2 levels, AMPK pathway changes, oxidative stress markers, and inflammatory gene levels, aged PS-MPs may stimulate E2 production and mobilize the liver AMPK signalling pathway of both male and female MAFLD mice. However, lipid metabolism is only affected in female MAFLD mice, suggesting other possible mechanisms besides the AMPK pathway may be at play. These results provide a new perspective on the potential health effects of MP exposure in individuals with metabolic disorders such as MAFLD.

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