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Mapping Clinical Disease Patterns Potentially Associated with Microplastic Exposure: A Narrative Review across Twenty-One Disease Categories
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This narrative review mapped clinical disease patterns potentially associated with microplastic exposure across 21 disease categories encompassing 375 illnesses. Researchers found emerging patterns linking microplastic and nanoplastic exposure to inflammatory, metabolic, and neurological outcomes, though the study emphasizes that many of these associations require further investigation to establish clear causal relationships.
Microplastics and Nanoplastics (MNPs) have emerged as pervasive environmental contaminants with growing evidence of systemic health effects. This study characterizes the spectrum of signs and symptoms associated with MNP exposure, examining potential mechanisms of toxicity, patterns of exposure, and biological responses. By integrating clinical observations and emerging experimental data, the research aims to clarify possible links between MNPs and inflammatory, metabolic, and neurological outcomes. Clinical data from 21 different classes of diseases, comprising of 375 illness were analyzed on the base of the 26 of the most common sign and symptoms, supplemented by to 4 variables related to the environment for a total of 30 (defined as Chicago Cluster System or CCS). Illnesses characterized by at least 8 signs were considered relevant. Association was explored though integration of the current literature. 40 diseases (21 chronic and 19 acute) across 12 different Classes were found to align with the 30 sign and symptoms of the CCS. Chronic illnesses included Alzheimer’s Disease, Parkinson, Diabetes Type 2, IrritableBowel Syndrome (IBS), Chronic Obstructive Pulmonary Disease (COPD), Rheumatoid arthritis, and Post Covid-19 syndrome, Acute illnesses included illnesses while Gastroenteritis, Pancreatitis, Meningitis, Acute Pneumonia and Acute hepatitis. The most represented sign and symptoms were fatigue, dyspepsia, C-Reactive Protein (CRP) increase, fever, cognitive changes, hematological abnormalities and imaging modifications. MNP exposure is associated with a multisystemic clinical presentation. These findings underscore the need to recognize MNPs as environmental cofactors in complex disease syndromes and to integrate clinical, biochemical, and imaging evidence in future epidemiological studies.
More Papers Like This
Mapping Clinical Disease Patterns Potentially Associated with Microplastic Exposure: A Narrative Review Across Twenty-One Disease Categories
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This research investigated the effects of microplastic exposure on lung surfactant function, examining how plastic particles interact with the lipid-protein layer lining the alveoli. The study found that microplastics can disrupt surfactant structure and function, potentially impairing respiratory mechanics and increasing pulmonary inflammation risk.
Micro- and Nanoplastics as Emerging Environmental Determinants of Human Health: A Narrative Review
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This narrative review explores evidence linking micro- and nanoplastic exposure to potential adverse health outcomes across multiple organ systems. Researchers found that increasing experimental and observational data suggest these particles may be associated with harmful biological effects. The review calls for further research to clarify the clinical significance of microplastic exposure for public health.
Micro- and Nanoplastics as Emerging Environmental Determinants of Human Health: A Narrative Review
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This narrative review explores the existing evidence linking micro- and nanoplastic exposure to potential health-related outcomes across multiple organ systems. Researchers found increasing experimental and observational evidence indicating that exposure to these particles may be associated with adverse biological effects. The review highlights the need for further clinical research to understand the full scope of microplastic impacts on human health.
A Systematic Review on the Impact of Micro-Nanoplastics Exposure on Human Health and Diseases
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This systematic review summarizes existing research on how micro and nanoplastic exposure affects human health and may contribute to disease. The evidence suggests that these tiny particles can enter the body through food, water, air, and even cosmetics, potentially causing inflammation, oxidative stress, and disruptions to the immune and reproductive systems.
[Clinical impact of microplastic exposure in humans].
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This review summarized clinical evidence on the health impacts of microplastic exposure in humans, covering routes of entry (air, food, contact) and the range of organ systems affected. It concluded that while data are still emerging, current evidence supports concern about microplastic accumulation and its potential to cause inflammation, oxidative stress, and systemic health effects.
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