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Article ? AI-assigned paper type based on the abstract. Classification may not be perfect — flag errors using the feedback button. Tier 2 ? Original research — experimental, observational, or case-control study. Direct primary evidence. Human Health Effects Marine & Wildlife Nanoplastics Policy & Risk Sign in to save

Neurological Outcomes of Joint Exposure to Polystyrene Micro/Nanospheres and Silver Nanoparticles in Zebrafish

Environmental Health Perspectives 2025 12 citations ? Citation count from OpenAlex, updated daily. May differ slightly from the publisher's own count.
Jie Song, Qian Pu, Chen Chen, Xingcheng Liu, Xinlei Zhang, Zejun Wang, Jin Yan, Jin Yan, Xuedong Wang, Huili Wang, Qiuhui Qian

Summary

This zebrafish study found that tiny nanoplastics made the brain-damaging effects of silver nanoparticles worse, while larger microplastics had less of an impact. The findings suggest that when nanoplastics combine with other common pollutants, they may create greater risks to the nervous system than either pollutant alone.

Polymers
PS
Body Systems
Nervous
Models
Zebrafish

Our findings demonstrate that polystyrene nanospheres (PSNPs) intensified AgNPs-induced neurotoxicity in larval zebrafish, whereas polystyrene microspheres (PSMPs) had a lesser effect, indicating distinct gene regulation roles when combined with AgNPs. These findings enhance the assessment of environmental risks in settings with coexisting nanomaterials and microplastics, offering important insights for evaluating combined exposure risks. https://doi.org/10.1289/EHP14873.

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