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Impact of Ps-mps on the Functioning of Epididymis and Seminal Vesicle in Wistar Albino Rats
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Researchers administered polystyrene microplastics to male Wistar rats at two dose levels and examined histological and functional changes in the epididymis and seminal vesicle. Microplastic exposure caused structural damage to both organs and disrupted secretory function, indicating that reproductive accessory glands are vulnerable to microplastic toxicity.
Microplastics enter the human body through plastic food packaging, food products, drinking water, and contaminated air.Microplastics produce negative impact on fertility of both males and females.In males, microplastics have been found to reduce sperm quality, testicular function, and overall fertility.The present study investigated the effects of polystyrene microplastics (PS-MPs) on the epididymis and seminal vesicle.Male Wistar albino rats were divided into groups based on administered doses of PS-MPs: 5, 50, 500, and 5000 g per kilogram of body weight.A sham control group was included for comparison.The study assessed organ weight, sperm characteristics, histological and biochemical parameters.The results revealed a dose-dependent decline in epididymal weight, ranging from 3% to International Journal of Current Research and Applied Studies (IJCRAS) Vol 4 Issue 2Mar-Apr 2025 11%.Sperm analysis showed a significant decline in sperm count, viability, and motility across all test groups.Morphological assessments of cauda epididymal sperm revealed higher prevalence of defects, including, bent tails, coiled tails, headless tails, and tail-less heads.Histological examination highlighted pronounced structural aberrations in the epididymis and seminal vesicle, particularly in animals treated with the highest dose of PS-MPs.Biochemical analysis showed a 35% reduction in sialic acid levels and diminished L-carnitine activity, indicating functional impairment of the epididymis.Additionally, reduced fructose levels in the seminal vesicle suggested a decline in the energy available in seminal fluid for ejaculated sperm.Overall, the study concluded that PS-MPs have a significant negative impact on the epididymis and seminal vesicle, likely affecting sperm maturation and post-ejaculation efficiency.
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Male rats exposed to increasing doses of polystyrene microplastics showed dose-dependent testicular damage including disrupted spermatogenesis and altered hormone levels, suggesting potential reproductive toxicity from microplastic accumulation.
Chronic toxic effects of polystyrene microplastics on reproductive parameters of male rats
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Researchers studied the chronic toxic effects of polystyrene microplastics on the reproductive system of male rats over 90 days. The study found significant reductions in sperm volume, motility, epididymal count, and serum testosterone levels, along with disrupted testicular architecture and decreased antioxidant capacity. The findings suggest that chronic microplastic exposure may adversely affect male reproductive parameters in mammals.
Impact of polystyrene microplastic exposure at low doses on male fertility: an experimental study in rats
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Researchers exposed adult male rats to varying doses of polystyrene microplastics and found dose-dependent declines in semen quality along with disrupted reproductive hormone levels. Higher doses caused increased oxidative stress, mitochondrial damage, and inflammatory responses in testicular tissue. The study suggests that even relatively low doses of microplastic exposure may have adverse effects on male reproductive health in animal models.
Polystyrene Microplastics Disrupt Spermatogenesis through Oxidative Stress in Rat Testicular Tissue
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Male Wistar rats orally administered polystyrene microplastics showed excessive oxidative stress in testicular tissue across all exposure groups, with spermatogenesis impairment and reduced fertility correlating with dose, demonstrating reproductive toxicity in a mammalian model.
Effects of 52-Day Oral Exposure to Fluorescent Polystyrene Microplastics on Hormonal Profile, Sperm Parameters, and Fertility in Male Wistar Rats
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Researchers exposed juvenile male rats to 1 µm and 5 µm fluorescent polystyrene microplastics across a full spermatogenesis cycle, finding size-dependent hormonal disruption—lower testosterone and estradiol with compensatory rises in FSH and LH—and impaired sperm quality, even though overall fertility remained intact and microplastics accumulated in testicular tissue.
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