BPS2026 – Visualizing the internalization and biological impact of nanoplastics in live organoid models using fluorescence lifetime imaging microscopy (FLIM)

Fluorescence imaging of microplastics and nanoplastics in biological samples

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Researchers reviewed fluorescence imaging techniques for detecting microplastics and nanoplastics in biological samples, highlighting advances in fluorescent dye staining, label-free autofluorescence detection, and super-resolution microscopy that can visualize particles as small as 50 nm inside living organisms.

Visualizing the internalization and biological impact of nanoplastics in live intestinal organoids by Fluorescence Lifetime Imaging Microscopy (FLIM)

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Researchers developed a new imaging method using fluorescence lifetime microscopy to track nanoplastics inside living intestinal tissue grown from stem cells, finding that even pristine (unweathered) PMMA and polystyrene nanoparticles disrupted mitochondrial function and triggered inflammation in gut cells within just three days.

Fluorescence Lifetime Imaging Microscopy (FLIM) visualizes internalization and biological impact of nanoplastics in live intestinal organoids

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Researchers developed a new imaging method using fluorescence lifetime microscopy to track how nanoplastics are taken up by lab-grown intestinal tissue models. They found that nanoplastics penetrated the outer cell layers and accumulated inside the organoids, causing measurable changes in cell metabolism. The technique offers a powerful new way to study how tiny plastic particles interact with living gut tissue in real time.

Microfluidic platforms for detection and biological evaluation of micro- and nanoplastics

Detection and characterization of microplastics and nanoplastics in biological samples

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Researchers reviewed current methods for detecting and characterizing microplastics and nanoplastics in biological samples, finding that most techniques are optimized for environmental media like water and perform poorly in complex biological matrices, and recommending improved workflows for digestion, separation, enrichment, and analysis of particles in organisms and human tissues.