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Mangosteen (garcinia Mangostana L.) Pericarp Extract Reduces Systemic Microplastic Burden by Preserving Intestinal Defense Mechanisms in Polyethylene Microplastic-exposed Rats
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In rats fed polyethylene microplastics, those also given mangosteen peel extract had lower microplastic particle counts in their blood. The extract was linked to higher levels of some gut bacteria, more IgA antibodies in feces, and changes in intestinal cells associated with gut barrier function.
Growing evidence indicates that ingested microplastics can disrupt intestinal barrier integrity and promote their translocation into systemic circulation, potentially leading to adverse health effects.This study investigated the protective effects of mangosteen (Garcinia mangostana L.) peel extract against the intestinal translocation of polyethylene microplastics in a Wistar rat model.A controlled in vivo experiment was conducted using thirty-five male Wistar rats randomly allocated into five groups: a negative control group, a polyethylene microplastic-exposed group (5 mg/day), and three treatment groups receiving Mangosteen (Garcinia mangostana L.) Pericarp Extract Reduces Systemic Microplastic Burden by Preserving Intestinal Defense Mechanisms in Polyethylene Microplastic-Exposed Rats IJDDT Volume 16 Issue 65s 2026 Page: 1866 polyethylene microplastics combined with mangosteen peel extract at doses of 200, 400, and 600 mg/kg body weight/day for 28 consecutive days.Polyethylene microplastic exposure significantly increased circulating microplastic particle counts in the blood and was associated with compromised intestinal barrier function.Treatment with mangosteen peel extract resulted in a dose-dependent reduction in blood microplastic levels.The protective effects were accompanied by increased total culturable gut microbiome abundance, enhanced fecal immunoglobulin A secretion, improved goblet cell density and mucus production, and elevated epithelial superoxide dismutase expression (all, p<0.05).These findings provide mechanistic evidence supporting the potential use of mangosteen-derived bioactive compounds as natural protective agents against microplastic-induced intestinal dysfunction and systemic exposure.
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