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Synthetic Biology-Enabled Green Biomanufacturing of Bio-based Platform Chemicals: A Review of Lactic Acid, Succinic Acid, 3-Hydroxypropionic Acid, and Adipic Acid
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This review summarizes existing research on using engineered microbes to produce four acids used as building blocks for biodegradable plastics. It covers genetic engineering methods researchers have used to improve microbial production of these chemicals, aiming to support more sustainable manufacturing.
Organic acids are significant bio-based platform chemicals with extensive application potential. The growing demand for biodegradable plastics, which utilize organic acids as their key monomers to mitigate plastic pollution, has been a major driver accelerating the advancement of organic acid biomanufacturing. This review systematically surveys recent progress in the biotechnological production of four representative organic acids, namely lactic acid, succinic acid, 3-hydroxypropionic acid, and adipic acid. And this review elaborates on the exploratory work directions currently being conducted by researchers on these organic acids. In particular, the applications of synthetic biology enabling strategies, such as synthetic biological components, genome editing technologies, metabolic engineering optimization, and adaptive laboratory evolution, for the development of high-performance microbial cell factories are systematically summarized. This review highlights the potential of emerging synthetic biology strategies in facilitating efficient and sustainable organic acid production and provides theoretical insights and practical guidance for the advancement of green biomanufacturing.
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Researchers reviewed biosynthetic pathways for producing 3-hydroxypropionic acid (3-HP), a key building block for biodegradable plastics, comparing three main metabolic routes — malonyl-CoA, beta-alanine, and glycerol pathways — across various microbial strains for scalable bio-based plastic production.
Bioplastic Production from Microbial Systems: Progress, Challenges, and Industrial Prospects
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This review surveys the current state of bioplastic production using microorganisms such as bacteria and fungi, highlighting recent advances in yield and material properties. It identifies key technical and economic challenges that limit commercial-scale adoption, including feedstock costs and fermentation efficiency. The authors outline promising research directions for making microbially produced bioplastics more competitive with petroleum-based alternatives.
Pivotal Role of Microbes in Solid Waste Management
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This review discusses the role of lactic acid bacteria in solid waste management, including their use as probiotics in food systems and their potential to produce polylactic acid (PLA), a biodegradable plastic. Using microbes to produce bioplastics that break down naturally could help reduce persistent microplastic pollution.
Bioplastics: Environment-friendly materials and their production technologies
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This review analyzes recent developments in bioplastics as an environmentally friendly alternative to conventional plastics, examining raw material sources, production technologies, and biodegradation assessment methods, with special emphasis on polylactic acid (PLA) as the most widely used biodegradable polymer.
Bioplastics and biodegradable plastics: A review of recent advances, feasibility and cleaner production
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Researchers systematically reviewed over 280 articles on bioplastics and biodegradable plastics, finding that while polylactic acid and polyhydroxyalkanoates reduce fossil fuel dependence, their higher production costs, lower durability, and tendency to form microplastics when improperly composted remain significant barriers to replacing conventional plastics.
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When a large batch of papers lands in the Atlas, we read through it and send a short write-up of what stood out.