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A Biosynthetic Pathway for 3-hydroxypropionic acid Production in Various Microbial Strains
Summary
Researchers reviewed biosynthetic pathways for producing 3-hydroxypropionic acid (3-HP), a key building block for biodegradable plastics, comparing three main metabolic routes — malonyl-CoA, beta-alanine, and glycerol pathways — across various microbial strains for scalable bio-based plastic production.
This review provides information on the characteristics and synthetic pathways of 3-hydroxypropionic acid (3-HP), a raw material for biodegradable plastics.The synthetic pathways of 3-HP are divided into three main routes: the malonyl-CoA pathway, the -alanine pathway, and the glycerol pathway.Each synthetic route is comparatively analyzed in terms of mechanism, efficiency, and economic feasibility.Consequently, 3-HP can be effectively produced as a biodegradable plastic through various synthetic pathways and efficient microbial strains.This review provides fundamental information on the mechanisms of 3-HP and its future research applications, emphasizing its potential to play a significant role as a key raw material for non-petroleum-based biodegradable plastics, which are environmentally friendly and economically advantageous.