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A Biosynthetic Pathway for 3-hydroxypropionic acid Production in Various Microbial Strains
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Researchers reviewed biosynthetic pathways for producing 3-hydroxypropionic acid (3-HP), a key building block for biodegradable plastics, comparing three main metabolic routes — malonyl-CoA, beta-alanine, and glycerol pathways — across various microbial strains for scalable bio-based plastic production.
This review provides information on the characteristics and synthetic pathways of 3-hydroxypropionic acid (3-HP), a raw material for biodegradable plastics.The synthetic pathways of 3-HP are divided into three main routes: the malonyl-CoA pathway, the -alanine pathway, and the glycerol pathway.Each synthetic route is comparatively analyzed in terms of mechanism, efficiency, and economic feasibility.Consequently, 3-HP can be effectively produced as a biodegradable plastic through various synthetic pathways and efficient microbial strains.This review provides fundamental information on the mechanisms of 3-HP and its future research applications, emphasizing its potential to play a significant role as a key raw material for non-petroleum-based biodegradable plastics, which are environmentally friendly and economically advantageous.
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This review examines the biosynthesis and recovery of polyhydroxyalkanoate (PHA), a microbially-produced biodegradable bioplastic that could replace petrochemical plastics and reduce microplastic pollution. The main barrier to commercialization is production cost, and the paper discusses strategies for making PHA economically viable at scale.
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This review covers the biological production of polyhydroxyalkanoates, a family of biodegradable bioplastics that bacteria naturally produce from waste carbon sources. Researchers found that these biopolymers have properties similar to conventional plastics like polypropylene but can fully biodegrade, making them a promising alternative to petroleum-based plastics. The study emphasizes that scaling up production and establishing proper end-of-life management are critical steps for PHAs to compete with conventional plastics and help reduce microplastic pollution.
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When a large batch of papers lands in the Atlas, we read through it and send a short write-up of what stood out.