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Microplastic and nanoplastic exposure accelerates atherosclerotic plaque formation in animal models: a systematic review and meta-analysis
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This review combines results from multiple studies in mice bred to develop artery disease, examining whether exposure to microplastics and nanoplastics affects the buildup of fatty plaques in blood vessels. It pools data on plaque amounts across studies to estimate an overall effect, while also checking for differences between studies and whether higher doses caused larger effects.
This systematic review and meta-analysis aims to evaluate whether microplastic and nanoplastic (MNP) exposure promotes atherosclerotic plaque formation in atherosclerosis-prone animal models (ApoE-/- or LDLR-/- mice). PubMed was searched for controlled studies with quantitative plaque outcomes. Plaque burden data were extracted or digitized from figures and pooled as standardized mean differences using DerSimonian-Laird random-effects models. Risk of bias was assessed with the SYRCLE tool. Expected outcomes include a pooled effect estimate, heterogeneity assessment, dose-response analysis, and sensitivity analyses.
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Microplastics and Atherosclerosis: Mechanisms
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This review examines the emerging evidence linking micro- and nanoplastic exposure to atherosclerosis, the buildup of plaques in blood vessel walls. Researchers found that these particles can enter the body through ingestion, inhalation, or skin contact and may promote cardiovascular damage through inflammation, oxidative stress, and immune activation. While direct causation has not been established, the study highlights the need for further research into how plastic pollution may affect heart and blood vessel health.
Microplastics in atherosclerosis could exacerbate the cardiovascular risk: A systematic review
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Tiny plastic particles called microplastics — which we're exposed to through food, water, and air — may be building up in the fatty deposits that clog our arteries, potentially making heart disease worse. This review pulls together existing research on the topic and suggests these plastic bits could be an overlooked risk factor for heart attacks and strokes, though scientists are still working out exactly how much harm they cause. If confirmed, this means reducing plastic exposure in daily life could become an important part of protecting heart health.
Micro- and nanoplastics in the cardiovascular system: current evidence, research gaps: a systematic review
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This systematic review examined how microplastics and nanoplastics affect the heart and blood vessels. Studies in both animals and human tissue found that these particles can cause blood vessel inflammation, disrupt heart function, and were even linked to higher rates of heart attack and stroke in people with plastic particles in their arteries.
Micro- and nanoplastics are elevated in femoral atherosclerotic plaques compared with undiseased arteries
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Researchers found significantly higher concentrations of microplastics and nanoplastics in diseased arterial plaques from human patients with limb-threatening vascular disease compared to healthy arteries, adding to growing evidence that these particles accumulate in cardiovascular tissue and may play a role in artery disease.
Micro and Nano-plastic particles: What are they and do they effect cardiovascular health?
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This review examines the cardiovascular health effects of micro- and nanoplastics, summarizing evidence that these particles have been detected in human tissues including arterial plaques and may promote endothelial dysfunction and inflammation. The authors call for further clinical and epidemiological research into cardiac risk.
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