F79. Dose-dependent Responses to Polystyrene Nanoplastics in Sh-sy5y Cells: Bioaccumulation, Antioxidant Adaptation, and Modulation of Upr/er Stress and Mitochondrial Oxidative Stress

Stress Response of Mouse Embryonic Fibroblasts Exposed to Polystyrene Nanoplastics

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Mouse embryonic fibroblasts exposed to polystyrene nanoplastics internalized particles via endocytosis without losing viability, but showed activation of antioxidant and autophagic stress pathways, suggesting subcellular dysfunction even in the absence of cell death.

Cellular Uptake and Nuclear Accumulation of Polystyrene Nanoplastics in 3T3 Fibroblasts and Hepatocytes of Rattus norvegicus

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Scientists found that tiny plastic particles called nanoplastics can get inside liver and connective tissue cells from rats, and even sneak into the cell's nucleus, where DNA is stored. Cells exposed to these plastics showed signs of stress and damage, including swelling and higher rates of cell death, suggesting these ultra-small plastic particles may be more harmful than previously thought. While this study used animal cells rather than human cells, it raises important questions about what everyday exposure to nanoplastics (found in food packaging, water, and other sources) might mean for our own cellular health.

Cytotoxicity of Polystyrene Nanoplastics Involves Mitochondrial Dysfunction and DNA Damage in Hemocytes of the Pacific Oyster

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Scientists found that tiny plastic particles (nanoplastics) can damage the immune cells of oysters by harming their mitochondria, the "batteries" that power cells, leading to DNA damage even at low exposure levels. While this study was done in oysters, not humans, it adds to growing evidence that nanoplastics can disrupt basic cell functions, raising questions about what similar exposure might mean for human health given how widespread plastic pollution has become in our food and water.

Author response for "Polystyrene Nanoplastic Exposure Promotes Amyloid Misfolding and Metabolic Impairment at Sub-Lethal Doses. A Subcellular Infrared Imaging Study"

Review for "Polystyrene Nanoplastic Exposure Promotes Amyloid Misfolding and Metabolic Impairment at Sub-Lethal Doses. A Subcellular Infrared Imaging Study"