P20-17 Size-dependent uptake and lysosomal accumulation of polystyrene nanoplastics in trophoblast cells

Cellular Uptake and Nuclear Accumulation of Polystyrene Nanoplastics in 3T3 Fibroblasts and Hepatocytes of Rattus norvegicus

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Scientists found that tiny plastic particles called nanoplastics can get inside liver and connective tissue cells from rats, and even sneak into the cell's nucleus, where DNA is stored. Cells exposed to these plastics showed signs of stress and damage, including swelling and higher rates of cell death, suggesting these ultra-small plastic particles may be more harmful than previously thought. While this study used animal cells rather than human cells, it raises important questions about what everyday exposure to nanoplastics (found in food packaging, water, and other sources) might mean for our own cellular health.

P-156 cellular uptake of polystyrene nanoplastics by oocytes and their impact on subsequent embryo development: a preliminary insight using a bovine in vitro model

Cellular Uptake, Transport, and Organelle Response After Exposure to Microplastics and Nanoplastics: Current Knowledge and Perspectives for Environmental and Health Risks

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Microplastics and nanoplastics enter cells through endocytosis and passive diffusion, then travel through organelles including endosomes, autophagosomes, and lysosomes, ultimately causing toxicity in mitochondria, endoplasmic reticulum, nucleus, and cytoskeleton. Understanding these cellular uptake pathways and organelle-level damage mechanisms is critical for accurately assessing the human health risks of chronic microplastic exposure.

Microplastics and nanoplastics in human health: a comprehensive review of exposure pathways, cellular mechanisms, and toxicological implications

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Researchers reviewed human exposure pathways to microplastics and nanoplastics through seafood, salt, drinking water, inhalation, and skin contact, examining how these particles cross biological barriers to reach organs and trigger oxidative stress, inflammation, and endocrine disruption with poorly understood long-term consequences.

Inside back cover

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This journal cover image is associated with research revealing the transport, uptake, and damage mechanisms of polystyrene microplastics in biological systems. The study examined how polystyrene particles move through organisms and what cellular or tissue damage results from their accumulation.