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Dataset and Source Code for: Extreme heat lowers the toxicity threshold of nanoplastics across cellular and ecological scales
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Note: this listing is a data/code repository supporting a study, not the full research paper, so key details about the actual experiments are limited here. Based on what's described, the underlying research suggests that as temperatures rise, tiny plastic particles (nanoplastics) may become harmful at much lower doses than previously thought, affecting cells and ecosystems alike. This matters because it hints that climate change and plastic pollution could combine to create health risks worse than either problem alone, though the specific human health implications would require reviewing the full study for details on what was actually tested.
This deposit contains the supporting numerical datasets, uncropped immunoblot source data, and custom analytical scripts for multi-omics integration, TTSI formulation, Bayesian MCMC sampling, and CMIP6 geospatial downscaling associated with the manuscript "TTSI-Climate-Nanoplastic". Methods Summary: Normality and homoscedasticity were tested (Shapiro-Wilk/Levene). Two-way ANOVA defined synergy, with t-tests, one-way ANOVA/Tukey, or Kruskal-Wallis/Dunn as appropriate. Multiple comparisons were FDR corrected (Benjamini-Hochberg; P < 0.01). Experiments were blinded and replicated ≥ 3 times. Analysis used R v4.6.0 and Prism v9.0. Complete statistical details are provided in the SI Appendix. External data: Raw sequencing data and processed count matrices for single-cell and spatial transcriptomics are available at NCBI GEO (GSE344086). Spatial metabolomics datasets are available at MetaboLights (MTBLS15251). Access for reviewers: This Zenodo entry is under restricted access for peer review. Editors and reviewers may access these materials anonymously via the private link generated for this deposit. All repositories will be made public upon manuscript acceptance, and the codebase will be mirrored on GitHub.
More Papers Like This
Dataset and Source Code for: Extreme heat lowers the toxicity threshold of nanoplastics across cellular and ecological scales
AI summary Read the abstract
This dataset release supports research suggesting that as temperatures climb due to climate change, tiny plastic particles (nanoplastics) may become more harmful to cells and ecosystems than previously thought, essentially, heat can lower the bar for how much plastic exposure causes damage. This matters because it hints that climate change and plastic pollution may worsen each other's health effects, though this specific release is the data and code behind the study rather than the full findings themselves.
Each temperature degree counts: warming enhances polystyrene nanoplastic toxicity via metabolic disruption in a marine cellular model
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This study examined how elevated water temperatures — simulating marine heatwaves — amplify the toxicity of polystyrene nanoplastics in marine cells, finding that warming enhanced metabolic disruption caused by nanoplastics. The results suggest climate change and plastic pollution interact synergistically to harm marine organisms.
Temperature and polystyrene nano- and microplastics co-exposure alters physiology and metabolome in the invasive snail Pomacea canaliculata
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Scientists found that warmer water makes tiny plastic particles (both microplastics and even smaller nanoplastics) more harmful to freshwater snails, disrupting their metabolism and stress-response systems, especially at high temperatures. This matters because as climate change warms our waterways, plastic pollution already in the environment could become more toxic to aquatic life, a concerning combination worth watching as these particles also make their way into the food we eat.
Elevated temperature decreases cardiovascular toxicity of nanoplastics but adds to their lethality: A case study during zebrafish (Danio rerio) development
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Researchers studied nanoplastic toxicity in developing zebrafish at different temperatures and found that while warmer water reduced cardiovascular defects, it actually increased overall mortality. Multi-omic analysis revealed that temperature shifted the type of damage nanoplastics caused, trading heart problems for more systemic lethal effects. This finding complicates predictions about nanoplastic risks under climate change scenarios.
Global warming enhances nanoplastics toxicity: Insights into body shrinkage and energy deficit
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Researchers studied how warming temperatures affect the toxicity of nanoplastics in water fleas over three generations. They found that elevated temperatures significantly worsened the harmful effects of polystyrene nanoplastics on growth, reproduction, and behavior. The underlying mechanism involved disruption of the animals' chitin-based exoskeleton development and energy metabolism, suggesting that climate change may amplify the ecological risks posed by nanoplastic pollution.
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