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Lactiplantibacillus plantarum PD01 from high excretion donor functions as a natural defense against microplastic toxicity
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In 138 people, the amount of microplastic found in stool varied with the abundance of the gut bacterium Lactiplantibacillus plantarum. Researchers isolated strain PD01 and gave it to mice on a mixed microplastic diet. Treated mice had 50 to 91% less of four plastics remaining in the intestinal tract, depending on the polymer.
Microplastics (MPs) present in a wide range of foods are a food safety concern due to their potential toxicity, yet effective approaches to enhance MPs clearance in the body remain lacking. Here, we first connected MPs excretion capacity to gut microbiota composition through a cross-sectional study of 138 individuals. Differential abundance and genomic variation of Lactiplantibacillus plantarum were observed between low- and high-excretion individuals. With this insight, we isolated L. plantarum PD01 from a high-excretion donor. In mice fed a mixed-MPs diet formulated to reflect human exposure, colonization with L. plantarum PD01 reduced 66.90% of PVC, 56.17% of PET, 91.35% of PS and 49.97% of PE remaining in the intestinal tract. Additionally, L. plantarum PD01 strengthened intestinal barrier integrity, promoted short-chain fatty acid production, alleviated inflammation, and restored gut microbiota dysbiosis caused by Mix-MPs. In vitro assays further validated PD01’s high capacity for MPs adsorption, protection of Caco-2 cells from MPs-induced damage, and reduction of MPs translocation in Caenorhabditis elegans . Collectively, our study uncovered specific gut microbiota features in humans with high MPs excretion and proposes a probiotic intervention strategy to reduce MPs accumulation and toxicity in the body.
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Lactobacillus plantarum reduces polystyrene microplastic induced toxicity via multiple pathways: A potentially effective and safe dietary strategy to counteract microplastic harm
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Mice exposed to polystyrene microplastics were given Lactobacillus plantarum strains that differed in antioxidant activity and in how well they bind the particles. Mice given strong binders had less polystyrene in the body and more in feces. A weakly binding strain also lowered toxicity, apparently through the intestinal barrier and bile acid metabolism.
Lactiplantibacillus plantarum PD01 supplementation reduces microplastics and microplastic-associated chemicals in humans: A randomized, double-blind, placebo-controlled trial
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In a randomized, double-blind, placebo-controlled trial, 106 participants took Lactiplantibacillus plantarum PD01 or a placebo three times a day. Urinary phthalate metabolites were the first measure analyzed, and they fell by roughly 35 to 60% after six weeks in the probiotic group.
Lactiplantibacillus plantarum P101 Alleviates Liver Toxicity of Combined Microplastics and Di-(2-Ethylhexyl) Phthalate via Regulating Gut Microbiota
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Researchers found that the probiotic Lactiplantibacillus plantarum P101 reduced liver damage caused by combined exposure to microplastics and the plasticizer DEHP in mice. The probiotic reversed oxidative stress and inflammation in the liver and intestines while reshaping the gut microbiota. The study suggests that probiotic supplementation may offer a promising strategy for mitigating the toxic effects of co-exposure to microplastics and plastic-associated chemicals.
Lactiplantibacillus plantarum F57 mitigates waterborne polypropylene microplastic-induced liver injury via gut microbiota modulation in zebrafish
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Zebrafish exposed to 50 micrometer polypropylene microplastics in water developed liver inflammation and oxidative stress. Among the Lactiplantibacillus plantarum strains tested, F57 was associated with the least liver injury and with a more diverse gut microbiota. Antioxidant capacity tracked with the result more closely than the strains' ability to bind the particles.
Novel probiotics adsorbing and excreting microplastics in vivo show potential gut health benefits
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Researchers screened 784 bacterial strains for the ability to bind polystyrene particles in the lab and selected two, L. paracasei DT66 and L. plantarum DT88. Mice given the strains passed 34% more polystyrene in feces and had 67% less left in the intestine. DT88 also lowered intestinal inflammation in the mice.
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