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Multi-omics exploration on polystyrene microplastic effects on term placental explants - Proteomics Raw Data
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Scientists exposed pieces of real human placenta tissue to microplastics (tiny plastic particles) in the lab, then used advanced protein-analysis technology to see how thousands of placental proteins changed in response. This study focused on generating and sharing the detailed protein data itself, laying groundwork for future research into whether microplastic exposure during pregnancy could affect placental function and, potentially, fetal health.
Global proteomic profiling was performed on human placental explants using a single-pot solid-phase-enhanced sample preparation (SP3) workflow followed by data-independent acquisition parallel accumulation–serial fragmentation (DIA-PASEF) on a timsTOF HT mass spectrometer coupled to a nanoElute LC system. Protein identification and quantification were carried out with DIA-NN v2.1.0 against the human reference proteome, using a 1% false discovery rate (FDR), allowing up to two missed cleavages, with carbamidomethylation (Cys) as a fixed modification and methionine oxidation as a variable modification. Match-between-runs was enabled to improve protein quantification across samples. After quality control, samples with insufficient protein yield were excluded, resulting in 6 control, 7 PS1, and 8 PS100 samples. Protein intensities were log-transformed and constant median normalized prior to statistical analysis. Two complementary analysis pipelines were employed: (i) filtering proteins with fewer than five valid values per group followed by missing-value imputation in Perseus, and (ii) analysis of the complete dataset without filtering or imputation. Downstream statistical analyses and visualization were performed in R using in-house scripts together with the ropls, ggpubr, rstatix, ComplexHeatmap, and EnhancedVolcano packages.
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Multi-omics exploration on polystyrene microplastic effects on term placental explants - Proteomics Raw Data
AI summary Read the abstract
Scientists exposed human placenta tissue (donated after birth) to tiny polystyrene microplastic particles in the lab, then used advanced protein-analysis technology to see how thousands of placental proteins changed in response. This is a foundational data-generating study, it maps out the proteins affected but doesn't yet draw conclusions about specific health risks, though it lays the groundwork for future research on whether microplastics could disrupt placental function during pregnancy.
Multi-omics integration reveals human placental molecular signatures associated with microplastics exposure
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Scientists studied human placenta tissue and found that higher levels of microplastics were linked to changes in genes, proteins, and metabolism, including signs of immune stress, oxidative damage, and problems with mitochondria (the energy-producing parts of cells). This is early evidence that microplastics may disrupt how the placenta functions, which matters because a healthy placenta is essential for delivering nutrients and oxygen to a developing baby. More research is needed to confirm whether these changes actually harm pregnancy outcomes, but the findings raise real questions about how everyday plastic exposure could affect maternal and fetal health
Adverse effects of a realistic concentration of human exposure to microplastics on markers of placental barrier permeability in pregnant rats
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Researchers exposed pregnant rats to polystyrene microplastics at concentrations realistic for human exposure and examined effects on the placenta. They found that the microplastics accumulated in placental tissue, caused oxidative stress, triggered cell death, and reduced the expression of proteins that maintain the placental barrier. The study provides the first evidence that realistic levels of microplastic exposure can compromise the protective barrier between mother and developing offspring.
Polystyrene microplastics induce biochemical and metabolism changes in human placental explants
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Researchers investigated the effects of polystyrene microplastics on human placental cells, finding that exposure altered biochemical pathways and metabolic activity. The results suggest that microplastics reaching the placenta can disrupt cellular functions important for fetal development.
Polystyrene microplastics induce biochemical and metabolism changes in human placental explants
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This study examined how polystyrene microplastics affect biochemical pathways and metabolism in human placental cells, with microplastics having been detected in human placental tissue. Polystyrene microplastics induced metabolic and biochemical changes in placental cells, raising concern for placental function and fetal health during pregnancy.
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