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Direct and Indirect Mitigation Strategies for Microplastic and Nanoplastic Exposure: A Conceptual Framework for Combination Therapeutic Development
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A technical note setting out a framework for future research on micro- and nanoplastic exposure. It separates direct strategies, aimed at particle levels or their contact with tissue, from indirect ones aimed at downstream effects such as inflammation. The authors state that the purpose is not to claim demonstrated clinical efficacy.
Microplastics and nanoplastics (MPs/NPs) are emerging environmental exposure agents with potential relevance to inflammation, oxidative stress, immune dysregulation, endothelial dysfunction, neuroinflammation, and long-term healthspan. Therapeutic development in this area may require both direct mitigation strategies, aimed at reducing particle burden or interaction with tissues, and indirect mitigation strategies, aimed at modulating downstream biological consequences. This technical note outlines a conceptual framework for direct and indirect MP/NP mitigation, including possible combination approaches with existing anti-inflammatory, metabolic, neuroprotective, cardiovascular, and immunomodulatory therapies. The purpose is not to claim demonstrated clinical efficacy, but to define a translational strategy for future testing, partnership development, and resilience-focused therapeutic design.
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