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A job exposure matrix for occupational exposure to airborne micro and nanoplastics (PlastiXJEM®) and associations with respiratory outcomes

Original title: A job exposure matrix for occupational exposure to airborne micro and nanoplastics (PlastiXJEM®) and associations with respiratory outcomes

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Researchers created a tool to estimate how much airborne microplastic exposure different jobs involve, then used it to study over 136,000 adults. They found that people with jobs involving higher microplastic exposure tended to have slightly lower lung function and more respiratory symptoms, though exposure wasn't linked to faster lung decline or new asthma over time. This suggests breathing in tiny plastic particles at work may affect lung health, but more research is needed to confirm and understand this connection.

Body Systems
Models

BACKGROUND: Microplastics and nanoplastics (MNP) are an increasingly recognized component of airborne particulate matter, yet their impact on respiratory health is unclear. This study aimed to develop a job exposure matrix (JEM) for occupational exposure to airborne MNP (PlastiXJEM®️ and examine its association with respiratory outcomes in the Lifelines cohort. METHODS: Four experts scored occupational airborne MNP exposure levels (none, low, high) for all ISCO-08 occupations based on documented sources and published evidence. After consensus, the PlastiXJEM®️ was applied to baseline current or last-held jobs of 136,928 adult Lifelines participants. Cross-sectional and longitudinal associations with lung function, respiratory symptoms, and asthma were assessed using linear and logistic regression models adjusted for age, sex, smoking, height, BMI, and co-exposure to organic dust, gasses and fumes, pesticides, metals, solvents and silica. RESULTS: and FVC in females only. Overall, effect sizes were larger at higher exposure levels, consistent with a dose-dependent pattern. MNP exposure was not associated with accelerated lung function decline or with the development of airway obstruction, respiratory symptoms, or asthma. CONCLUSION: Occupational exposure to airborne MNP is associated with lower lung function and a higher prevalence of respiratory symptoms in this cohort. These findings warrant further investigation with complete occupational histories.

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