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Enterohepatic Circulationof Polystyrene NanoplasticsPromotes Intestinal Inflammation by Impairing Enteric Neurons
Summary
New research in mice found that tiny plastic particles (nanoplastics) don't just pass through your gut—once absorbed, they get pulled into the liver and gallbladder, then recycled back into the intestines through bile, allowing them to build up over time instead of being cleared out. This repeated exposure damaged the gut lining, disrupted healthy gut bacteria, and harmed nerve cells that help control gut function, leading to inflammation. While this study was done in mice, it suggests that ongoing plastic exposure could have compounding effects on gut health that are worth taking seriously as we learn more about how microplastics affect the human
Microplastics (MPs) are emerging contaminants of increasing concern, yet their in vivo fate and mechanisms of intestinal toxicity remain poorly defined. Here, we demonstrate that polystyrene nanoplastics (PS-NPs) undergo a previously overlooked enterohepatic recirculation pathway that markedly enhances their intestinal retention. Using oral exposure and a Zombie mouse model with intravenous PS-NPs delivery, we show that systemically absorbed PS-NPs are efficiently captured by the liver, concentrated in the gallbladder, and subsequently reintroduced into the intestine via bile. Chronic PS-NPs exposure caused pronounced epithelial injury, including goblet cell loss, tight-junction disruption, and robust cytokine-mediated inflammation. Multiomics analyses revealed gut microbial dysbiosis, extensive shifts in metabolite profiles, and enrichment of neuroactive signaling pathways, suggesting microbiome-metabolite contributions to toxicity. We further identified significant enteric neurotoxicity characterized by reduced expression of vasoactive intestinal peptide, increased expression of tyrosine hydroxylase, and downregulation of the mechanosensitive PIEZO1 channel. Together, these findings establish hepatobiliary recycling as a key driver of intestinal PS-NPs accumulation and demonstrate that epithelial damage, microbiome-metabolite imbalance, and enteric nervous system dysfunction collectively mediate PS-NPs-induced gut pathology. This work provides mechanistic insights essential for evaluating the health risks of environmental PS-NPs exposure.