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Spatial Ppara-Anxa2 Axis in Polyethyelen-Driven Liver Damage
Summary
Researchers used spatial transcriptomics to map how polyethylene microplastics disrupt liver cell populations in mice, revealing inflammatory hotspots with reduced cellular diversity and identifying the Ppara-Anxa2 signaling axis as a key molecular driver of PE-associated liver damage.
Microplastics (MP) are increasingly recognized as an urgent global health concern, with mounting evidence linking their bioaccumulation to chronic disease risks. The liver, as a central organ for metabolic homeostasis and detoxification, is particularly sensitive to sustained MP exposure. However, the mechanisms underlying hepatic responses to polyethylene (PE), the most prevalent yet relatively understudied plastic type, remain poorly defined. Spatial transcriptomics uncovered the cell-type heterogeneity and gene expression patterns masked in bulk analyses. Spatial clustering uncovered inflammatory hotspots characterized by reduced cellular diversity and distinct PE-responsive gene signatures. This study provides a molecular framework for understanding MP-associated disruption of liver pathophysiology and highlights potential targets for therapeutic intervention. Here we share the shinyapp versions. 1) Mouse_MP_Polyethylene_Hepatocytes_Cholangiocytes https://ohbiolab.shinyapps.io/shinyApp_MP_Polyethylene_Hepatocytes/ 2) Mouse_MP_Polyethylene_NonParenchymal https://ohbiolab.shinyapps.io/shinyApp_MP_Polyethylene_NonParenchymal/ 3) Mouse_MP_Polyethyelen_downsize_20pct (for better loading speed) https://ohbiolab.shinyapps.io/shinyApp_MP_Polyethylene_downsize_20pct/