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Long-term Low-dose Nanoplastic Exposure Induces Neurotoxicity with Oxidative Brain Damage-Transcriptomics Data
Summary
Researchers exposed male mice to polystyrene nanoplastics via drinking water for 17 months and used transcriptomic analysis of brain tissue to show significant upregulation of Alzheimer's and Parkinson's disease pathways, alongside unexpected activation of cardiovascular disease networks, indicating that chronic low-dose exposure reshapes systemic molecular circuitry.
This study aims to investigate the long-term effects of chronic exposure to polystyrene nanoplastics (PS-NPs) on systemic molecular networks, with a particular focus on neurodegenerative. Transcriptomic analysis revealed significant upregulation of pathways associated with Alzheimer disease, Parkinson disease, even cardiovascular disease pathways like diabetic cardiomyopathy which is quite surprising, indicating systemic molecular network reorganization driven by prolonged PS-NPs exposure. Sample Information: Animal model: 5-week-old male C57BL/6J mice Experimental duration: 17 months Group design: Control group (n=3): standard sterile drinking water PS-NPs group (n=3): drinking water supplemented with polystyrene nanoplastics Exposure route: continuous oral administration via drinking water; water bottles replaced weekly Tissue collected: brain tissue Endpoint: upon the first natural death among all mice, the remaining animals were euthanized