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Co-exposure to polystyrene nanoparticles and tetrabromobisphenol A induces genotoxicity and disrupts intestinal barrier differentiation
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Researchers evaluated the combined toxicity of polystyrene nanoparticles and the flame retardant tetrabromobisphenol A on differentiated human intestinal Caco-2 cells, finding co-exposure induced genotoxicity and disrupted intestinal barrier differentiation beyond effects observed with either contaminant alone.
This dataset was generated throughout two projects funded by the Spanish Researh Agency: "Use of fish and human cellular models to evaluate the toxicological impact of nano/microplastics as vehicles of flame retardants" (RTI2018-096046-B-C22) and "Generation of in vitro assays to establish the activity of cellular stress pathways as beacons of toxicological effects of dietary additives and contaminants in human intestinal cells" (PID2022-141894OB-C22). This study evaluated the effects of TBBPA-PSNPs co-exposure on human intestinal barrier integrity and function using differentiated Caco-2 cells and Caco-2/HT29-MTX co-cultures as validated in vitro models.
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Influence of polystyrene nanoparticles on the toxicity of tetrabromobisphenol A in human intestinal cell lines
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When human intestinal cells were exposed to both polystyrene nanoparticles and the flame retardant TBBPA together, the chemical pollutant dominated the toxic response, causing oxidative stress, DNA damage, and disruption of mitochondrial function. The study shows that mixing microplastics with other contaminants can produce complex, hard-to-predict health effects in gut cells, which matters because people are routinely exposed to multiple pollutants at once.
Influence of polystyrene nanoparticles on the toxicity of tetrabromobisphenol A in human intestinal cell lines
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Researchers tested the combined toxicity of polystyrene nanoparticles and the flame retardant tetrabromobisphenol A (TBBPA) in human intestinal cell lines, finding that TBBPA dominated the toxic response in mixtures, inducing oxidative stress, mitochondrial damage, and DNA strand breaks even at sub-lethal concentrations.
Influence of the co-exposure of microplastics and tetrabromobisphenol A on human gut: Simulation in vitro with human cell Caco-2 and gut microbiota
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Researchers studied the combined effects of polyethylene microplastics and the flame retardant TBBPA on human gut cells and gut bacteria in laboratory experiments. The study found that both substances damaged human intestinal cells, with TBBPA playing the larger role, while microplastics amplified certain harmful effects at high concentrations. TBBPA also selectively killed beneficial gut bacteria like Lactobacillus while promoting potentially harmful species, and microplastics enhanced this imbalance.
Detrimental effects of individual versus combined exposure to tetrabromobisphenol A and polystyrene nanoplastics in fish cell lines
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Researchers tested how combined exposure to the flame retardant tetrabromobisphenol A and polystyrene nanoparticles affects freshwater fish cells. They found that co-exposure to even low concentrations of both pollutants caused subtle changes in cell viability and generated oxidative DNA damage. The study suggests that the interaction between nanoplastics and chemical pollutants in aquatic environments may pose compounding risks to fish health.
Polystyrene nanoparticles aggravate the adverse effects of di-(2-ethylhexyl) phthalate on different segments of intestine in mice
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Researchers exposed mice to polystyrene nanoparticles and the plasticizer DEHP simultaneously, finding that co-exposure caused greater intestinal damage — including shorter villi, disrupted tight junctions, and reduced mucus coverage — than either contaminant alone, with gut microbiota alterations likely contributing to the enhanced toxicity.
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When a large batch of papers lands in the Atlas, we read through it and send a short write-up of what stood out.