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Co-exposure to polystyrene nanoparticles and tetrabromobisphenol A induces genotoxicity and disrupts intestinal barrier differentiation
Summary
Researchers evaluated the combined toxicity of polystyrene nanoparticles and the flame retardant tetrabromobisphenol A on differentiated human intestinal Caco-2 cells, finding co-exposure induced genotoxicity and disrupted intestinal barrier differentiation beyond effects observed with either contaminant alone.
This dataset was generated throughout two projects funded by the Spanish Researh Agency: "Use of fish and human cellular models to evaluate the toxicological impact of nano/microplastics as vehicles of flame retardants" (RTI2018-096046-B-C22) and "Generation of in vitro assays to establish the activity of cellular stress pathways as beacons of toxicological effects of dietary additives and contaminants in human intestinal cells" (PID2022-141894OB-C22). This study evaluated the effects of TBBPA-PSNPs co-exposure on human intestinal barrier integrity and function using differentiated Caco-2 cells and Caco-2/HT29-MTX co-cultures as validated in vitro models.