We can't find the internet
Attempting to reconnect
Something went wrong!
Hang in there while we get back on track
Positive effects of gamma aminobutyric acid on growth and lipopolysaccharide induced intestinal mucosal barrier damage in snakehead (Channa argus)
Summary
Supplementing snakehead fish (Channa argus) with gamma-aminobutyric acid improved growth performance and mitigated lipopolysaccharide-induced intestinal barrier damage, with GABA supplementation restoring tight junction protein expression and reducing intestinal permeability.
Abstract Lipopolysaccharides (LPS) impairs intestinal barrier function by disrupting intestinal permeability. Reasonably supplementing gamma aminobutyric (GABA) or regulating its levels has a positive effect on promoting fish growth and improving intestinal health. Therefore, it is valuable to investigate the effects of GABA on snakehead growth and LPS-induced intestinal mucosal barrier damage. In this study, a model for intestinal mucosal barrier damage was created by administering 1.0 mg/mL LPS injection into anus over a period of 96 h in snakehead. Prior to LPS challenge, fish [(5.19 ± 0.12) g] were fed with different levels of GABA (0, 30, 60, 90 and 120 mg/kg) for 56 d. Results showed that LPS induced obvious intestinal damage, while GABA effectively alleviated this phenomenon. In addition, intestinal permeability-related parameters (DAO and LPS) were dramatically increased in LPS group, while these parameters dramatically decreased in remission groups. Correspondingly, LPS altered species composition, α-diversity and β-diversity in biological barrier; digestive enzymes (AMY, LIP and TRY) and gastrointestinal hormones (CCK and GHRL) in chemical barrier; tight junction structures and tight junction-related genes (claudin-1, claudin-5, occludin and zo-1) in physical barrier and inflammatory factors (IL-1β and TNF-α) and immune-related genes (igm, igt, mhc-Ⅰ and pigr) in immune barrier. Nevertheless, the addition of GABA to feed effectively improved LPS-induced intestinal mucosal barrier damage. Therefore, GABA positively impacted growth and LPS-induced intestinal damage in snakehead, which provided a favorable foundation for the nutritional regulation of their intestinal mucosal barrier.
Sign in to start a discussion.
More Papers Like This
Immunonutrition: facilitating mucosal immune response in teleost intestine with amino acids through oxidant-antioxidant balance
This review explores how specific amino acids can boost the immune response in the intestines of fish by modulating oxidative stress and antioxidant balance. Researchers found that nutrients like glutamine, arginine, and tryptophan help strengthen the mucosal immune barrier in the fish gut, which is important for disease resistance in aquaculture. While focused on fish health, the findings contribute to broader understanding of how nutrition influences gut immunity across species.
The Combination of β-Glucan and Astragalus Polysaccharide Effectively Resists Nocardia seriolae Infection in Largemouth Bass (Micropterus salmoides)
Researchers tested a combination of beta-glucan and astragalus polysaccharide as a natural immunostimulant to help largemouth bass resist a common bacterial infection. The supplement combination was as effective as conventional antibiotics in improving fish survival rates and reducing bacterial loads. The study suggests that natural polysaccharide supplements could offer a viable alternative to antibiotics in aquaculture for managing disease outbreaks.
Fermented Wheat Bran Polysaccharides Improved Intestinal Health of Zebrafish in Terms of Intestinal Motility and Barrier Function
Researchers found that fermented wheat bran polysaccharides improved intestinal health in zebrafish by enhancing intestinal motility and barrier function, suggesting their potential as functional food additives for gut health.
Dietary Curcumin Promotes Gilthead Seabream Larvae Digestive Capacity and Modulates Oxidative Status
Adding curcumin to the diet of gilthead seabream larvae improved their digestive capacity and antioxidant status. The research explores natural dietary supplements for improving fish health in aquaculture, which is relevant as farmed seafood is a source of microplastic exposure for humans.
Effect of Probiotic Supplimentations on the Gut Histoarchitecture of Stinging Catfish, Heteropneustes fossilis
This aquaculture study evaluated the effects of probiotic supplementation on gut histology in stinging catfish, finding that probiotics improved intestinal morphology—relevant to understanding how gut health modifications may influence susceptibility to microplastic-induced gastrointestinal damage.