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Reply to “Comment on ‘Polylactic Acid Micro/Nanoplastic Exposure Induces Male Reproductive Toxicity by Disrupting Spermatogenesis and Mitochondrial Dysfunction in Mice’”

ACS Nano 2026

Summary

This is a scientific back-and-forth (not a new study) where researchers defend their earlier finding that tiny plastic particles from PLA, a "biodegradable" plastic used in things like food packaging and 3D printing, can harm sperm production and cell energy function in male mice. The exchange addresses valid criticism about whether the type of plastic breaks down differently in the body, but doesn't overturn the original concern: even "eco-friendly" plastics may pose reproductive health risks that deserve more research before we assume they're safe alternatives to regular plastic.

Polymers
Body Systems

W e thank Dr. Liu and colleagues for their interest in our work and for raising the valid point that polymer stability and biodegradation are relevant variables in nanotoxicology

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