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Polystyrene nanoplastics trigger pyroptosis in dopaminergic neurons through TSC2/TFEB-mediated disruption of autophagosome-lysosome fusion in Parkinson’s disease

Journal of Translational Medicine 2025 11 citations ? Citation count from OpenAlex, updated daily. May differ slightly from the publisher's own count. Score: 68 ? 0–100 AI score estimating relevance to the microplastics field. Papers below 30 are filtered from public browse.

Xiaomei Liang, Chengyu Chen Chengyu Chen Chengyu Chen Yaqi Zeng, Chengyu Chen Piao Zhang, Baoyu Zhu, Chengyu Chen Baoyu Zhu, Jiezhu Feng, Jiezhu Feng, Tongtong Deng, Tongtong Deng, Chengyu Chen Zhongling Fu, Zhongling Fu, Chengshuai Liu, Chengshuai Liu, Chengshuai Liu, Chengshuai Liu, Chengshuai Liu, Chengshuai Liu, Chengshuai Liu, Chengyu Chen Chengyu Chen Chengyu Chen Yuhu Zhang, Chengyu Chen Chengyu Chen Chengyu Chen Chengyu Chen Chengyu Chen Chengyu Chen Chengyu Chen Chengyu Chen

Summary

This study found that polystyrene nanoplastics accelerated the onset and progression of Parkinson's disease in lab models by disrupting the brain cells' waste-clearing system. The nanoplastics interfered with how brain cells break down damaged proteins, triggering a type of inflammatory cell death in the dopamine-producing neurons that are critical for movement control.

Polymers

Body Systems

Nervous

These findings underscore how PS-NPs accelerated PD onset and progression by disrupting autophagosome-lysosome fusion through TSC2-mTOR-TFEB axis, which triggered protein degradation disorders and pyroptosis in dopaminergic neurons. The molecular mechanisms could inform environmental safety regulations concerning nanoplastics and inspire therapeutic strategies for PD.

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