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Article ? AI-assigned paper type based on the abstract. Classification may not be perfect — flag errors using the feedback button. Tier 2 ? Original research — experimental, observational, or case-control study. Direct primary evidence. Human Health Effects Nanoplastics Policy & Risk Remediation Sign in to save

Polystyrene nanoplastics trigger pyroptosis in dopaminergic neurons through TSC2/TFEB-mediated disruption of autophagosome-lysosome fusion in Parkinson’s disease

Journal of Translational Medicine 2025 11 citations ? Citation count from OpenAlex, updated daily. May differ slightly from the publisher's own count.
Xiaomei Liang, Yaqi Zeng, Piao Zhang, Baoyu Zhu, Jiezhu Feng, Tongtong Deng, Zhongling Fu, Chengshuai Liu, Chengyu Chen, Yuhu Zhang

Summary

This study found that polystyrene nanoplastics accelerated the onset and progression of Parkinson's disease in lab models by disrupting the brain cells' waste-clearing system. The nanoplastics interfered with how brain cells break down damaged proteins, triggering a type of inflammatory cell death in the dopamine-producing neurons that are critical for movement control.

Polymers
PS
Body Systems
Nervous

These findings underscore how PS-NPs accelerated PD onset and progression by disrupting autophagosome-lysosome fusion through TSC2-mTOR-TFEB axis, which triggered protein degradation disorders and pyroptosis in dopaminergic neurons. The molecular mechanisms could inform environmental safety regulations concerning nanoplastics and inspire therapeutic strategies for PD.

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