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Article ? AI-assigned paper type based on the abstract. Classification may not be perfect — flag errors using the feedback button. Tier 2 ? Original research — experimental, observational, or case-control study. Direct primary evidence. Human Health Effects Sign in to save

Polystyrene microplastics induces the injury of human corneal epithelial cells through ROS-mediated p53 pathway

Mutagenesis 2025 2 citations ? Citation count from OpenAlex, updated daily. May differ slightly from the publisher's own count. Score: 58 ? 0–100 AI score estimating relevance to the microplastics field. Papers below 30 are filtered from public browse.
Jianfeng Long, Jianfeng Long, Jianfeng Long, Jianfeng Long, Limin Deng, Jian Li, Kang Zhou, Shijie He Shijie He, Shijie He, Shijie He

Summary

Researchers found that polystyrene microplastics caused significant damage to human corneal eye cells, including cell cycle arrest, necrosis, and programmed cell death. The damage was driven by an overproduction of reactive oxygen species that activated a key stress-response pathway in the cells. The study suggests that microplastic exposure may pose risks to eye health, particularly for the cells that form the outermost layer of the cornea.

Polymers

PS-MP exposure leads to cell cycle arrest, necrosis, and apoptosis in HCEP cells, which is associated with ROS overproduction and activation of the P53 pathway.

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