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Protective Effect of Biobran/MGN-3, an Arabinoxylan from Rice Bran, Against the Cytotoxic Effects of Polyethylene Nanoplastics in Normal Mouse Hepatocytes: An In Vitro and In Silico Study
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An in vitro and in silico study found that Biobran/MGN-3 (an arabinoxylan rice bran extract) protected normal mouse hepatocytes against cytotoxic effects of polyethylene nanoplastics, suggesting a potential hepatoprotective role for this dietary supplement.
These findings highlight the potential use of Biobran as a hepatoprotector against NP toxicity.
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“Polyethylene Terephthalate Nanoplastics Caused Hepatotoxicity in Mice Can be Prevented by Betaine: Molecular and Immunohistochemical Insights”
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Researchers found that polyethylene terephthalate nanoplastics caused significant liver damage in mice, including elevated liver enzymes, oxidative stress, and inflammation. When mice were given betaine, a naturally occurring compound, alongside the nanoplastics, the liver damage was substantially reduced. The study suggests that betaine may offer a protective effect against nanoplastic-induced liver toxicity, pointing to potential dietary strategies for mitigating harm from plastic particle exposure.
Protection of Exogenous Antioxidant of Cinnamomum burmanii as a Hepatoprotective on the Toxicological Responses of Nanoplastics in Rats (Rattus norvegicus L.)
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Researchers tested whether Cinnamomum burmanni leaf extract (CLE) protects rat liver function from polystyrene nanoplastic toxicity, administering NPs orally for 14 days with or without 100–400 mg/kg CLE for 28 days. NPs caused oxidative stress and liver damage, while CLE at 200–400 mg/kg significantly reduced hepatotoxicity markers and restored antioxidant enzyme activity, suggesting hepatoprotective potential against nanoplastic-induced toxicity.
Attenuative effects of poncirin against polyethylene microplastics-prompted hepatotoxicity in rats
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Researchers tested whether poncirin, a natural plant compound, could protect rat livers from damage caused by polyethylene microplastics. They found that microplastic exposure caused significant oxidative stress, inflammation, and liver tissue damage, which poncirin was able to substantially reduce by activating protective antioxidant pathways. The study suggests that natural compounds like poncirin may help counteract some of the harmful effects of microplastic exposure on the liver.
High fiber diet mitigates exposure risk of nanoplastics in male mice
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Mice fed a higher-fiber diet retained less of a swallowed nanoplastic dose than mice on a standard diet, and had less intestinal damage and lower nanoplastic levels in the liver. In separate lab tests, the fiber bound to the nanoplastic particles.
Polyethylene terephthalate nanoplastics-induced neurotoxicity in adult male Swiss albino mice with amelioration of betaine: a histopathological, neurochemical, and molecular investigation
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Mice exposed to PET nanoplastics (the type found in food packaging and cosmetics) showed signs of brain damage including increased inflammation, oxidative stress, and reduced levels of a key brain enzyme. The study also found that the supplement betaine significantly protected against this brain damage, suggesting a potential way to counteract nanoplastic-related neurotoxicity.
Research digests by email
When a large batch of papers lands in the Atlas, we read through it and send a short write-up of what stood out.