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Effects of combined exposure to heavy metals on lower respiratory flora and its role of lung injury in rats

Frontiers in Microbiology 2025 2 citations ? Citation count from OpenAlex, updated daily. May differ slightly from the publisher's own count. Score: 58 ? 0–100 AI score estimating relevance to the microplastics field. Papers below 30 are filtered from public browse.
Ping Ding, Ping Ding, Xiaoxia Wang, Nan Li, Shuxia Yu, Yiwen Zhang, Junpu Yu, Tian Tian, Rentong Chen, Bin Luo, Li Ma, Rongxuan Zhang

Summary

Researchers found that combined exposure to nickel, copper, and arsenic disrupted the natural microbial communities in the lower respiratory tract of rats and caused lung damage. The heavy metal mixture altered the balance of beneficial and harmful bacteria in the airways, which was linked to impaired lung function. The findings highlight how environmental exposure to multiple metals simultaneously may harm respiratory health by disrupting the lung's natural microbiome.

Body Systems
Models

Combined exposure to Ni, Cu, and As disrupts respiratory microbiota and impairs lung function in rats. These findings highlight a critical link between environmental heavy metal exposure and respiratory health, underscoring the need for stricter regulation of metal pollutants and further research into microbiota-related lung injury mechanisms.

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