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Influence of microplastics on antibiotic resistance genes across diverse environments: A comprehensive meta and machine-learning analysis
Summary
This large-scale analysis examined how microplastics influence the spread of antibiotic resistance genes across different environments including intestines, wastewater sludge, plants, soil, and water. Researchers found that microplastics significantly boosted antibiotic resistance gene levels in gut, sludge, and plant settings, with particle size and concentration being the most important factors. The findings suggest that microplastic pollution may be helping spread antibiotic resistance, a serious public health concern, through multiple environmental pathways.
The coexistence of microplastics (MPs) and antibiotic resistance genes (ARGs) in various environments presents significant ecological risks. However, the influence of MPs properties and environmental conditions shaping ARG dynamics remain unclear. This study utilized meta- and interaction analysis to elucidate how MPs properties (size, concentration, type, and age) and exposure environments drive ARGs fluctuations. Key findings indicate that MPs significantly influenced ARGs abundance in intestinal, sludge, and plant environments, no pronounced effects were observed in soil or water and sediments. Among the MPs properties, size and concentration were the most influential factors, with their impacts varying considerably across environments. In intestinal settings, exposure time and MPs concentration drove ARG proliferation; while the concentration-size interactions of MPs shaped ARGs in sludge environments; MPs size was the primary influencing factor in plant environments, reflecting unique ARG dynamics in these contexts. The study also highlighted significant pairwise interactions, such as MPs concentration and size, underscoring the combined effects of these factors on ARG abundance. Despite these contributions, the study acknowledges limitations, including the limited analysis of aerosolized ARGs and more diverse MPs characteristics. These findings provide valuable insights into the ecological risks of MPs and ARGs and emphasize the importance of tailored mitigation strategies across different environments.