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Letter to the Editor Concerning “Simultaneous, Single-Particle Measurements of Size and Loading Give Insights into the Structure of Drug-Delivery Nanoparticles”
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This letter discusses the problem of excess variance in nanoparticle size distribution measurements, which degrades accuracy in applications from lipid nanoparticle quality control to nanoplastic hazard assessment. The correspondence highlights how measurement precision limitations affect our ability to characterize nanoscale plastic particles in environmental and biomedical contexts.
The vexing error of excess variance in measurements of nanoparticle size distributions degrades accuracy in applications ranging from quality control of nanoparticle products to hazard assessment of nanoplastic byproducts.The particular importance of lipid nanoparticles for vaccine and medicine delivery motivates
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Letter to the Editor Concerning "Simultaneous, Single-Particle Measurements of Size and Loading Give Insights into the Structure of Drug-Delivery Nanoparticles"
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This is a letter to the editor critiquing measurement errors in a published study on sizing drug delivery nanoparticles. The author argues that excess variance in particle sizing methods undermines the validity of the original findings and could mislead applications in both pharmaceutical and nanoplastic hazard assessment contexts. The letter proposes that measurement error models are needed to address this widespread issue.
Characterizing nanoplastic suspensions of increasing complexity: inter-laboratory comparison of size measurements using dynamic light scattering
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An inter-laboratory comparison evaluated methods for characterizing nanoplastic suspensions of increasing complexity, highlighting the lack of well-characterized test materials as a major barrier to reliable nanoplastic toxicity studies. The study aimed to improve harmonization of nanoplastic size and property measurements across research groups.
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Researchers explored the question of how small nanoplastic particles can actually be, highlighting the lack of standardized size definitions for this emerging pollutant. They examined the analytical challenges involved in detecting and characterizing nanoplastics at the smallest scales. The study calls for a clearer framework around nanoplastic size boundaries, since particle size is a key factor influencing toxicity and environmental behavior.
Investigation and correction of size-dependent transport efficiencies of microparticles in SP ICP-MS analysis.
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Researchers systematically measured how single-particle ICP-MS transport efficiency declines sharply for microplastics above 3 µm in diameter — a size range where conventional constant-TE assumptions break down — and developed a sigmoidal correction model using flow cytometry as an independent reference, showing that without this correction both particle size distributions and number concentrations are systematically biased toward smaller particles.
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