Modifications de sondes de type Quantum Dot pour la détection de polluants

Endocrine-disrupting chemicals (EDCs) have become a worldwide environmental issue due to population explosion and industrial prosperity. EDCs are among the most concerning emerging contaminants because of suspicion as carcinogens alter the human body's reproductive, neurological, and immune functions. Bisphenol A (BPA) is one of the most alarming phenolic-EDCs widely used as an additive to enhance plastic's hardness and thermal stability. However, the discharged BPA from manufacturing factories or wastewater treatment plants is suspected of causing diseases related to the hormone due to the estrogen-like effect. In order to prevent the threat of BPA, massive efforts have been devoted to the development of BPA detection.Two quantum dots (QDs)-based detection systems were constructed in this project: (1) an aptamer-mimetic sensing system based on functionalized amylose/QDs composite, and (2) an ingenious copolymer/QDs fluorescent microgels sensor. These two systems exhibit a considerably wide detection range, low limit of detection (LOD), and fast response time. Moreover, these fluorescent systems can directly detect the analyte in the water without pretreatment. In addition, both systems demonstrated selective sensing for BPA compounds over 5 other phenolic chemicals. Besides, the preparation and sensing conditions were optimized for each sensor, and the sensing mechanisms were also validated during this thesis.