We can't find the internet
Attempting to reconnect
Something went wrong!
Hang in there while we get back on track
Epigenetic Changes in the HTR8 and 3A-sub E placental Cell Lines Exposed to Bisphenol A and Benzyl Butyl Phthalate
AI summary Read the abstract
This study shows that exposure to bisphenol A and benzyl butyl phthalate causes epigenetic methylation changes in human placental cells, with effects observed specifically in first-trimester HTR8-SVneo cells, suggesting a window of heightened susceptibility to these common plastic-associated chemical pollutants during early pregnancy.
The results of this study demonstrate the capability of epigenetic changes in human placenta cells induced by bisphenol A and benzyl butyl phthalate. The observed methylation changes only in the first-trimester HTR8-SVneo cells phthalate may reflect a window of epigenetic susceptibility related to these environmental toxicants.
More Papers Like This
The Silent Legacy: Paternal and Maternal Exposure to Microplastics and Differential DNA Methylation in Human Oocytes and Zygotes
AI summary Read the abstract
This review examined evidence that both paternal and maternal microplastic exposures can alter DNA methylation patterns in human oocytes and zygotes, with potential intergenerational reproductive consequences. The authors found that phthalates and BPA carried by microplastics are likely epigenetic disruptors at the earliest stages of human development, though direct mechanistic evidence in humans remains limited.
Pollution and the Genome: Genotoxic and Epigenetic Effects — Review
AI summary Read the abstract
This review summarizes existing research on how pollutants, including particulate matter, metals, PAHs, pesticides, and plasticizers like BPA and phthalates, can damage DNA or change how genes are read without altering DNA sequence. Evidence from human studies, cells, and animals was strongest for particulate matter, and exposure before birth to lead, BPA, or phthalates was linked to gene-reading changes lasting into childhood in humans and adulthood in mice.
Associations Between Behavioral Effects of Bisphenol A and DNA Methylation in Zebrafish Embryos
AI summary Read the abstract
Researchers exposed zebrafish embryos to bisphenol A (BPA) and found that even very low concentrations altered swimming behavior and produced over 20,000 differentially methylated DNA sites across nearly 5,000 genes, with the most affected genes linked to nervous system development and synaptic function.
Environmental Xenobiotics and Epigenetic Modifications: Implications for Human Health and Disease
AI summary Read the abstract
This review examines how environmental pollutants, including microplastics, can change gene activity through epigenetic modifications without altering DNA itself. These changes to how genes are turned on and off can contribute to cancer, brain diseases, and developmental problems, and may even be passed down to future generations. The research highlights that microplastics and other common pollutants could have long-lasting health effects that go beyond direct chemical toxicity.
Sex-specific effects of prenatal bisphenol A exposure on transcriptome-interactome profiles of autism candidate genes in neural stem cells from offspring hippocampus
AI summary Read the abstract
Researchers exposed pregnant rats to bisphenol A (BPA), a chemical found in many plastics, and examined how it affected the brain stem cells of offspring, finding that male pups showed significantly greater disruption to genes linked to autism spectrum disorder. The results suggest that prenatal BPA exposure may contribute to the higher rates of autism seen in males by altering how key brain genes are expressed during early development.
Research digests by email
When a large batch of papers lands in the Atlas, we read through it and send a short write-up of what stood out.