Epigenetic Changes in the HTR8 and 3A-sub E placental Cell Lines Exposed to Bisphenol A and Benzyl Butyl Phthalate

Christian Litton; Paula Benny; Luca Lambertini; Yula Ma; Jonathan M. Riel; Rodrigo Barbano Weingrill; Johann Urschitz; Jia Chen; Men‐Jean Lee

doi:10.3390/toxics12090659

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Epigenetic Changes in the HTR8 and 3A-sub E placental Cell Lines Exposed to Bisphenol A and Benzyl Butyl Phthalate

Cambridge Prisms Plastics 2024 1 citation ? Citation count from OpenAlex, updated daily. May differ slightly from the publisher's own count.

Christian Litton, Paula Benny, Luca Lambertini, Yula Ma, Jonathan M. Riel, Rodrigo Barbano Weingrill, Johann Urschitz, Jia Chen, Men‐Jean Lee

Summary

This study shows that exposure to bisphenol A and benzyl butyl phthalate causes epigenetic methylation changes in human placental cells, with effects observed specifically in first-trimester HTR8-SVneo cells, suggesting a window of heightened susceptibility to these common plastic-associated chemical pollutants during early pregnancy.

Body Systems

Reproductive

The results of this study demonstrate the capability of epigenetic changes in human placenta cells induced by bisphenol A and benzyl butyl phthalate. The observed methylation changes only in the first-trimester HTR8-SVneo cells phthalate may reflect a window of epigenetic susceptibility related to these environmental toxicants.

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