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Exposure to High Concentrations of Tetrabromobisphenol A Slows the Process of Tissue Regeneration and Induces an Imbalance of Metabolic Homeostasis in the Regenerated Intestines of Apostichopus japonicus
Physical Chemistry Chemical Physics
2024
2 citations
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Citation count from OpenAlex, updated daily. May differ slightly from the publisher's own count.
Zi Wang,
Xiaojun Song,
Wenhui Yin,
Kun Shi,
Ying Lin,
Jixiang Liu,
Xiaohan Li,
Jiabo Tan,
Junjie Rong,
Kefeng Xu,
Guodong Wang
Summary
Researchers found that high concentrations of tetrabromobisphenol A (TBBPA), a common flame retardant, slow intestinal tissue regeneration in sea cucumbers and disrupt metabolic homeostasis by altering the expression of key transcription factors in regenerating gut tissue.
These results suggested that high levels of exposure to TBBPA induces an imbalance of the metabolic homeostasis by regulating the expression levels of transcription factors in the regenerated intestines of A. japonicus.