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Exposure to High Concentrations of Tetrabromobisphenol A Slows the Process of Tissue Regeneration and Induces an Imbalance of Metabolic Homeostasis in the Regenerated Intestines of Apostichopus japonicus
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Researchers found that high concentrations of tetrabromobisphenol A (TBBPA), a common flame retardant, slow intestinal tissue regeneration in sea cucumbers and disrupt metabolic homeostasis by altering the expression of key transcription factors in regenerating gut tissue.
These results suggested that high levels of exposure to TBBPA induces an imbalance of the metabolic homeostasis by regulating the expression levels of transcription factors in the regenerated intestines of A. japonicus.
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Microplastic exposure in freshwater planarians disrupted their tissue regeneration capacity and cellular homeostasis, with effects worsening at higher concentrations. Planarians are valued model organisms for studying regeneration, and these findings suggest microplastics can impair fundamental biological repair processes in aquatic invertebrates.
Influence of the co-exposure of microplastics and tetrabromobisphenol A on human gut: Simulation in vitro with human cell Caco-2 and gut microbiota
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Researchers studied the combined effects of polyethylene microplastics and the flame retardant TBBPA on human gut cells and gut bacteria in laboratory experiments. The study found that both substances damaged human intestinal cells, with TBBPA playing the larger role, while microplastics amplified certain harmful effects at high concentrations. TBBPA also selectively killed beneficial gut bacteria like Lactobacillus while promoting potentially harmful species, and microplastics enhanced this imbalance.
The Exposure to Polypropylene Micro- and Nanoplastics Impairs Wound Healing and Tissue Regeneration in the Leech Hirudo verbana
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Researchers studied how polypropylene micro- and nanoplastics affect wound healing and tissue regeneration in the freshwater leech Hirudo verbana. They found that plastic exposure induced fibrosis, disrupted tissue reorganization, delayed wound repair, and activated innate immune and oxidative stress responses. The study provides the first evidence that polypropylene particles can impair tissue regeneration processes in living organisms.
DEHP chronic exposure disturbs the gut microbial community and metabolic homeostasis: Gender-based differences in zebrafish
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Chronic exposure of zebrafish to DEHP — a phthalate plasticizer found in many plastic products — from embryo to adulthood disrupted gut microbial communities and metabolic balance, with effects that differed between males and females. This suggests that phthalate exposure from plastic products may alter gut health and metabolism in ways that could be relevant to human health.
Microplastics induce intestinal inflammation, oxidative stress, and disorders of metabolome and microbiome in zebrafish
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Researchers exposed zebrafish to polystyrene microplastics for 21 days and found significant intestinal inflammation, oxidative stress, and disruption of both the gut microbiome and metabolic processes. The microplastics altered the balance of beneficial and harmful gut bacteria and changed the levels of key metabolites involved in energy and amino acid metabolism. The study provides detailed evidence that microplastic ingestion can cause widespread disruption to gut health in aquatic organisms.
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