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Developmental toxicity and mechanism of dibutyl phthalate on the development of subintestinal vessels in zebrafish
Summary
Researchers exposed zebrafish embryos to dibutyl phthalate (DBP), a common plastic plasticizer, and found it caused abnormal development of subintestinal blood vessels by increasing oxidative stress and disrupting the HIF signaling pathway. These findings provide mechanistic insight into how DBP interferes with vascular development during early life stages.
DBP induced vascular developmental toxicity by enhancing oxidative stress levels, activating HIF pathway, and interfering with the expression of vascular development-related pathways in zebrafish, results in the abnormal development of the subintestinal vessels in zebrafish.