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Developmental toxicity and mechanism of dibutyl phthalate on the development of subintestinal vessels in zebrafish
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Researchers exposed zebrafish embryos to dibutyl phthalate (DBP), a common plastic plasticizer, and found it caused abnormal development of subintestinal blood vessels by increasing oxidative stress and disrupting the HIF signaling pathway. These findings provide mechanistic insight into how DBP interferes with vascular development during early life stages.
DBP induced vascular developmental toxicity by enhancing oxidative stress levels, activating HIF pathway, and interfering with the expression of vascular development-related pathways in zebrafish, results in the abnormal development of the subintestinal vessels in zebrafish.
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New insight into long-term effects of phthalates microplastics in developing zebrafish: Evidence from genomic alteration and organ development
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Researchers investigated the long-term developmental effects of three common plasticizers (DBP, DEP, and DEHP) leaching from microplastics on zebrafish larvae. The study found that phthalate exposure caused higher mortality, morphological abnormalities, and significant changes in genes related to cardiovascular development, tail formation, and other critical developmental pathways.
In vivo toxicity of Dioctyl Phthalate in adult and zebrafish larvae.
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Researchers tested the toxicity of the plasticizer dioctyl phthalate on zebrafish embryos and adults, finding developmental abnormalities and dose-dependent organ damage including fatty liver, renal necrosis, and oligospermia, with larvae more sensitive than adults.
Probing the Cardiovascular Toxic Effects of Long-Term Exposure to Dibutyl Phthalate in Sprague-Dawley Rats Based on Oxidative Inflammation and Metabolic Pathways: Implications for the Heart and Blood Vessel
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This study investigates the effects of prolonged microplastic exposure on cardiovascular health, examining how particles accumulate in cardiac tissues and disrupt normal function. Researchers documented toxic responses including inflammation, oxidative stress, and structural changes in heart and vascular tissue. The findings raise concern about the long-term cardiovascular risks posed by chronic microplastic exposure in humans and animals.
Nanoplastics exposure induces vascular malformation by interfering with the VEGFA/VEGFR pathway in zebrafish (Danio rerio)
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Researchers found that nanoplastics exposure causes vascular malformation in zebrafish embryos by disrupting the VEGFA/VEGFR signaling pathway, providing new insight into how plastic nanoparticles can impair cardiovascular development.
Exposure to Nanoplastics Cause Caudal Vein Plexus Damage and Hematopoietic Dysfunction by Oxidative Stress Response in Zebrafish (Danio rerio)
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Researchers found that nanoplastic exposure in zebrafish embryos caused damage to blood vessel development and impaired the formation of blood cells. The nanoplastics triggered oxidative stress in vascular and blood-forming cells, disrupting normal developmental processes. The study suggests that nanoplastic contamination in aquatic environments could affect early development in fish by interfering with their circulatory and blood cell production systems.
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