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Per- and polyfluoroalkyl substances (PFAS) as environmental drivers of antimicrobial resistance: insights from genome sequences of Klebsiella grimontii and Citrobacter braakii isolated from contaminated soil
ACS Agricultural Science & Technology
2025
3 citations
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Citation count from OpenAlex, updated daily. May differ slightly from the publisher's own count.
Matteo Calcagnile,
Andrea Giuliano,
Salvatore Maurizio Tredici,
Davide Gualandris,
D. Rotondo,
Antonio Calisi,
Chiara Leo,
Maurizio Martelli,
Anna Rocchi,
Knud Erik Klint,
Francesco Dondero,
Pietro Alifano
Summary
Researchers showed through microcosm experiments that PFOA, a common PFAS compound, selects for antibiotic-resistant bacteria and increases transcription of antimicrobial resistance genes, suggesting that environmental PFAS contamination may contribute to the spread of antibiotic resistance.
Study Type
In vitro
In vitro microcosm experiments showed that PFOA (perfluorooctanoic acid) selects for antibiotic-resistant bacteria, characterized by WGS, which displayed increased transcription of AMR genes during growth in the presence of PFOA.