We can't find the internet
Attempting to reconnect
Something went wrong!
Hang in there while we get back on track
Towards a Better Understanding of the Human Health Risk of Per- and Polyfluoroalkyl Substances Using Organoid Models
AI summary Read the abstract
This review argues that human organoids — stem cell-derived 3D tissue models — offer a more relevant platform than traditional animal studies or cell cultures for assessing the health risks of PFAS (per- and polyfluoroalkyl substances), as they better replicate the multicellular architecture of human organs and could help clarify the toxic mechanisms behind PFAS-linked diseases.
The ubiquitous presence of per- and polyfluoroalkyl substances (PFAS) in the environment has garnered global public concern. Epidemiological studies have proved that exposure to PFAS is associated with human health risks. Although evidence demonstrated the toxic mechanisms of PFAS based on animal models and traditional cell cultures, their limitations in inter-species differences and lack of human-relevant microenvironments hinder the understanding of health risks from PFAS exposure. There is an increasing necessity to explore alternative methodologies that can effectively evaluate human health risks. Human organoids derived from stem cells accurately mimic the sophisticated and multicellular structures of native human organs, providing promising models for toxicology research. Advanced organoids combined with innovative technologies are expected to improve understanding of the breadth and depth of PFAS toxicity.
More Papers Like This
Human organoids to assess environmental contaminants toxicity and mode of action: towards New Approach Methodologies
AI summary Read the abstract
This review explores how human organoids, miniature lab-grown organ models, can be used to test the toxicity of environmental contaminants including microplastics. These 3D tissue models offer a more accurate picture of how pollutants affect human cells than traditional lab tests, though more work is needed to simulate the chronic, low-dose exposures people actually experience.
Advancing Microplastic and Nanoplastic Toxicity Assessment: Insights from Human Organoid Models
AI summary Read the abstract
This review examines how human stem cell-derived organoids are being used to study the toxic effects of microplastics and nanoplastics on human tissues. Researchers found that organoid models of the gut, lung, brain, and other organs provide more human-relevant data than traditional animal testing for assessing plastic particle toxicity. The study suggests that organoid technology could significantly advance understanding of how microplastics affect human health at the tissue and organ level.
Application of organoid technology in the human health risk assessment of microplastics: A review of progresses and challenges
AI summary Read the abstract
This review examines how organoid technology -- miniature lab-grown versions of human organs made from stem cells -- can be used to study the health effects of microplastics more accurately than traditional animal testing. Organoids of the gut, lung, brain, liver, and other organs can better predict how microplastics affect human tissues, potentially accelerating our understanding of the real health risks these particles pose.
Organoid-based platforms for investigating microplastic-induced human organ toxicity
AI summary Read the abstract
This review examines how lab-grown miniature organ models, called organoids, are being used to study the health effects of micro- and nanoplastic exposure on human tissues. Evidence from brain, heart, lung, liver, kidney, and intestinal organoid models shows that plastic particles can cause oxidative stress, inflammation, cell death, and impaired tissue development. The technology offers a more realistic way to study plastic toxicity compared to traditional cell culture or animal experiments.
Engineering human midbrain organoid microphysiological systems to model prenatal PFOS exposure
AI summary Read the abstract
Scientists grew tiny lab-made models of a developing human brain and exposed them to PFOS, a "forever chemical" found in water, food packaging, and household products. They found that PFOS exposure disrupted normal brain cell activity and development while triggering inflammation, offering early evidence of how these chemicals might affect a fetus's developing brain. This mini-brain model could help researchers test other common pollutants (including those linked to plastics) for similar risks, without needing to experiment on humans or animals.
Research digests by email
When a large batch of papers lands in the Atlas, we read through it and send a short write-up of what stood out.