We can't find the internet
Attempting to reconnect
Something went wrong!
Hang in there while we get back on track
Metabolite Monomethyl Phthalate (MMP) Induces Oxidative Damage in Rat Erythrocytes: Role of Vitamins C and E
AI summary Read the abstract
Researchers found that monomethyl phthalate (MMP), a metabolite of the plasticizer dimethyl phthalate, induces significant oxidative damage to rat red blood cells, and that vitamins C and E can partially protect against this toxicity, linking phthalate exposure to cellular oxidative stress.
Dimethyl phthalate (DMP) can enter the human body and be absorbed into the bloodstream to produce monomethyl phthalate (MMP). MMP in the environment can also enter the bloodstream. However, little is known about the toxicity of the phthalate metabolite MMP in most organisms. In this study, the erythrocyte toxicity of MMP and a preventive approach were investigated using Sprague-Dawley (SD) rats as the model animal under MMP concentrations of 5-250 mg/kg (sub-chronic exposure in vivo) and 1.25-100 μg/mL (acute exposure in vitro). The experimental results indicate that the interaction of MMP with erythrocytes caused oxidative damage, which decreased the number of red blood cells and the hemoglobin content and increased the content of methemoglobin and the iron release of hemoglobin in rat blood. However, the above results were not observed when MMP directly interacted with hemoglobin. The antioxidants vitamin C and vitamin E improved the above blood indicators in rats. The results of this study provide certain theoretical guidance for the evaluation of the potential risks of phthalate metabolites.
More Papers Like This
Natural Antioxidants Effect on the Performance of Erythrocytes, Leucocytes, and Hb Levels of Pregnant Mice Exposed to the Plastic
AI summary Read the abstract
Researchers exposed pregnant mice to chemical compounds leached from HDPE plastic and tested whether natural antioxidant juices (carrot, orange, purple sweet potato, mung bean sprouts) could protect blood cell health, finding no significant impact on erythrocyte or leucocyte counts but evidence that antioxidants may help stabilize red blood cell levels after treatment ends.
Hemotoxic effects of polyethylene microplastics on mice
AI summary Read the abstract
Researchers exposed mice to different concentrations of polyethylene microplastics for 15 days and studied the effects on their blood. The highest dose caused significant damage to red blood cells, leading to abnormal shapes and reduced blood cell counts, along with impaired liver and kidney function. The study suggests that microplastic exposure may have harmful effects on blood health in mammals, including patterns consistent with anemia.
Exploring Hematologic Effects of Microplastics: Urinary Mono-n-butyl Phthalate and Blood Cell Counts
AI summary Read the abstract
This study investigated whether urinary mono-n-butyl phthalate (MBP), a biomarker of phthalate exposure and indirect indicator of microplastic exposure, is associated with hematologic effects in humans. Elevated MBP levels were linked to changes in blood cell counts and coagulation markers, suggesting microplastic-associated phthalate exposure may affect hematopoietic function.
Are Polymeric Microparticles Dangerous for Red Blood Cells?
AI summary Read the abstract
This review of existing research shows that tiny plastic particles (microplastics) found in human blood can damage red blood cells by making them less flexible and even killing them. When red blood cells become damaged, they can't carry oxygen as well throughout the body, which could affect blood flow and overall health. While scientists need more research to understand the full health risks, this is concerning because microplastics are becoming more common in our environment and bodies.
Pengaruh Mikroplastik Polyethylene Terephthalate (PET) Terhadap Profil Eritrosit Tikus Betina Galur Wistar
AI summary Read the abstract
This animal study tested how PET microplastics (common in plastic bottles) affect blood cells in rats. Results showed that exposure to PET microplastics may lower red blood cell counts, hemoglobin, and hematocrit levels, suggesting potential effects on blood health that warrant further investigation in humans.
Research digests by email
When a large batch of papers lands in the Atlas, we read through it and send a short write-up of what stood out.