We can't find the internet
Attempting to reconnect
Something went wrong!
Hang in there while we get back on track
Urinary Bisphenol Mixtures at Population-Exposure Levels Are Associated with Diabetes Prevalence: Evidence from Advanced Mixture Modeling
AI summary Read the abstract
This study investigated the association between urinary bisphenol A (BPA), bisphenol S (BPS), and bisphenol F (BPF) levels and diabetes in a general adult population using advanced mixture modeling methods including weighted quantile sum and quantile G-computation. Results showed a significant positive association between combined bisphenol exposure and elevated HbA1c and diabetes prevalence, with BPS emerging as a particularly concerning BPA substitute.
Humanity lives in a new era marked by the ubiquitous presence of plastics worldwide. Recent figures highlight continuous growth in plastic production and usage, a trend paralleled by the rise in chronic diseases like diabetes. The multifactorial nature of these diseases suggests that environmental exposure, notably to bisphenol A (BPA), could be a contributing factor. This study investigates the potential correlation between emerging BPA substitutes, bisphenol S and F (BPS and BPF), and diabetes in a cohort of the general adult population. Findings reveal a positive association between combined bisphenols (BPs) and glycated haemoglobin (Hb1Ac), with binomial logistic regression demonstrating an odds ratio (OR) of 1.103 (1.002-1.214) between BP levels corrected for creatinine (crucial due to glomerular filtration variations) and diabetes. Advanced statistical methods, including Weighted Quantile Sum (WQS) and quantile G-computation analysis, show a combined positive effect on diabetes, glucose levels, and Hb1Ac. Individual effect analysis identifies BPS as a significant monomer warranting attention in future diabetes-related research. Ultimately, replacing BPA with new molecules like BPS or BPF may pose a greater risk in the context of diabetes.
More Papers Like This
Urinary Bisphenol Mixtures at Population-Exposure Levels Are Associated with Diabetes Prevalence: Evidence from Advanced Mixture Modeling
AI summary Read the abstract
This study used NHANES data and advanced mixture modeling to examine combined exposure to bisphenols BPA, BPS, and BPF in U.S. adults, finding a significant positive association between the bisphenol mixture and diabetes prevalence, with BPS identified as a particularly concerning substitute for BPA.
A mixture analysis of urinary microplastic levels and risk of gestational diabetes
AI summary Read the abstract
A study of pregnant women found novel evidence that urinary microplastic levels were associated with impaired glucose regulation, suggesting that microplastic exposure may contribute to the risk of gestational diabetes.
Temporal and geographic variability of bisphenol levels in humans: A systematic review and meta-analysis of international biomonitoring data
AI summary Read the abstract
Researchers conducted a systematic review and meta-analysis of global biomonitoring data and found evidence of increasing population-wide exposure to bisphenol A (BPA) and the replacement chemical BPS, raising concerns about the chemicals' impact on public health and economies worldwide.
Temporal patterns of bisphenol exposure in the Czech population within the framework of regulatory measures
AI summary Read the abstract
This study tracked bisphenol exposure in Czech populations across two time periods and found that while BPA levels declined by up to 47.5% in children following regulatory restrictions, BPS concentrations surged by over 90% in children and 121% in adults — suggesting that BPA substitutes are rising as a new exposure concern.
Combined Effect of Metals, PFAS, Phthalates, and Plasticizers on Cardiovascular Disease Risk
AI summary Read the abstract
This study used Bayesian Kernel Machine Regression on NHANES data to assess how mixtures of metals, PFAS, phthalates, and plasticizers collectively affect cardiovascular markers, finding that phthalates and plasticizers were major contributors to altered LDL, blood pressure, and cholesterol levels, with the overall mixture associated with increased cardiovascular disease risk.
Research digests by email
When a large batch of papers lands in the Atlas, we read through it and send a short write-up of what stood out.