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Vitamin A attenuates PFOS-induced neurotoxicity and alters early proximity patterns to conspecifics in zebrafish larvae
Summary
Researchers found that PFOS exposure disrupts dopamine signaling and triggers apoptosis in zebrafish larvae, impairing early social behavior, while supplementation with vitamin A partially counteracted these neurotoxic effects, suggesting a potential protective role against PFOS-induced developmental neurotoxicity.
Our findings demonstrate that PFOS disrupts early social neurodevelopment through dopaminergic dysregulation and apoptotic signaling, while vitamin A exhibits counteractive potential. this study elucidates the impact of PFOS exposure on zebrafish social behavior and brain development. while highlighting the neuroprotective potential of vitamin A against PFOS exposure, These findings have significant guiding implications for the development of public health policy and provide a scientific foundation for comprehending the neurotoxicity of PFOS and developing effective intervention measures.