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Analysis of the effects of acetyl tributyl citrate on bone cancer based on network toxicology and molecular docking

Lecture notes in civil engineering 2025 1 citation ? Citation count from OpenAlex, updated daily. May differ slightly from the publisher's own count.
Lujun Jiang, Juncheng Shen, Jinghong Yang, Zi Wang, Lian Tang, Yuqi Li, Jialin Liu, Zhong Li, Yanshi Liu

Summary

Researchers used network toxicology and molecular docking to investigate how acetyl tributyl citrate (ATBC), a common plasticizer, may promote bone cancer by activating key signaling proteins including STAT3, EGFR, and MMP9, suggesting the chemical can drive tumor progression by remodeling the tumor microenvironment.

This study underscores the potential carcinogenic effects of ATBC in bone cancer, identifying key targets such as STAT3, EGFR, MMP9, MAPK1, and MMP2. The findings indicate that ATBC may facilitate the progression of bone cancer by targeting essential signaling pathways and remodeling the tumor microenvironment. This emphasizes the necessity for further research into the environmental risks associated with this plasticizer.

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