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Impact of Di-(2-Ethylhexyl)-Phthalate on Metabolic Syndrome: Insights from Network Toxicology and Molecular Docking and Dynamics
Summary
This study used network toxicology and molecular docking to investigate how the common plasticizer DEHP (di-(2-ethylhexyl) phthalate) may contribute to metabolic syndrome, identifying key molecular targets and pathways through which DEHP exposure could exacerbate metabolic dysfunction, though experimental validation of these mechanistic findings remains needed.
Our study highlights the interaction between environmental pollutants and metabolic dysfunction. These findings highlight the potential role of DEHP in exacerbating MetS and provide a basis for mitigating its health risks through targeted interventions. Further experimental validation is needed in the future to confirm these mechanistic insights.