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Gida Güvenli̇ği̇ İle Çevre Ve İnsan Sağliği Açisindan Çevresel Ki̇rleti̇ci̇leri̇n Oral Yoldan İn Vi̇tro Bi̇yoeri̇şi̇lebi̇li̇rli̇ği̇ Çalişmalarinin Detayli Bi̇r İncelemesi̇
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This Turkish review examined in vitro oral bioaccessibility studies for environmental pollutants including microplastics, organic pollutants, and heavy metals, focusing on the fraction available for intestinal absorption during digestion. The review synthesizes how internal and external factors affect bioaccessibility and underscores that environmental concentration alone does not capture true human exposure or health risk.
Today, many factors, including globalization, global population growth, industrial development, and the rapid expansion of industrial areas, lead to the release of environmental pollutants into the biosphere. Many pollutants, such as organic pollutants, heavy metals, and microplastics, directly threaten food safety, human health, and environmental health. When assessing the risks of environmental pollutants to human and environmental health, the concentration of pollutants in the environment is generally considered, while the amount of the pollutant absorbed into the human body is often overlooked. At this point, the concept of "bioaccessibility," which has become a focus in recent years and refers to the amount of compounds released from food matrices during the digestive process and available for absorption through the intestinal wall, comes to the fore. This review provides a detailed review of in vitro oral bioaccessibility studies on environmental pollutants. Based on current knowledge, we attempt to provide an overview of how the bioaccessibility of environmental pollutants is affected by internal and external factors.
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