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Microplastic exposure induces epithelial barrier alterations and increases collagen deposition in a 3D human endometrial model in vitro
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Researchers exposed a 3D human endometrial tissue model to microplastics in the laboratory and observed alterations to the epithelial barrier along with increased collagen deposition. The findings suggest that microplastics may have the ability to exert harmful effects on human endometrial tissue. The study raises concerns about a possible negative impact on uterine functionality and receptivity.
The data obtained suggest MP ability to exert deleterious effects in vitro on human endometrium, with a possible negative impact on its functionality and receptivity.
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Assessing the Impact of Polyethylene Nano/Microplastic Exposure on Human Vaginal Keratinocytes
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Researchers exposed human vaginal skin cells to polyethylene micro and nanoplastics similar to what might be released from disposable period products. At high concentrations, the plastic particles were taken up by cells and caused cell death, inflammation, and oxidative stress. This is the first study to address this specific exposure route, highlighting a potential women's health concern from microplastics in menstrual products.
Microplastic-induced inhibition of cell adhesion and toxicity evaluation using human dermal fibroblast-derived spheroids
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Researchers developed a three-dimensional cell model using human skin cells to test how microplastics affect cell behavior and adhesion. They found that microplastic exposure significantly reduced the ability of cells to stick together and form proper tissue structures. The study provides new evidence that microplastics may interfere with basic cellular functions relevant to skin health and wound healing.
Detection and quantification of microplastics in endometrial polyps and their role in polyp formation
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Researchers detected and compared microplastic levels between normal uterine lining tissue and endometrial polyps, finding significantly higher concentrations of polyethylene, polystyrene, and PVC in the polyp tissue. They also discovered that polystyrene microplastics can promote the growth and migration of uterine lining cells through a specific cellular signaling pathway, which may contribute to polyp formation. This is the first study to link microplastic accumulation in reproductive tissue to a common gynecological condition that can affect fertility.
Investigation of potential toxic effects of nano- and microplastics on human endometrial stromal cells
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Researchers exposed human endometrial cells (uterine lining cells) to polystyrene nano- and microplastics and found that smaller particles (100 nanometers) were taken up most readily, accumulating in both the nucleus and cytoplasm. At higher concentrations, the nanoplastics reduced cell growth and triggered cell death. These findings suggest that nanoplastics could pose a risk to uterine health and potentially affect fertility and pregnancy outcomes.
Microplastic accumulation in endometrial cancer tissues and its metabolic impact
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Researchers examined microplastic levels in endometrial cancer tissues compared to normal tissue and found that cancer tissues contained significantly higher concentrations of plastic particles. The most common plastics detected were polyethylene, polypropylene, and polystyrene. Metabolic analysis revealed that microplastic presence was associated with changes in cancer-related metabolic pathways, suggesting that microplastics may play a role in promoting tumor development through metabolic reprogramming.
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