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Top-down generated micro- and nanoplastics reduce macrophage viability without eliciting a pro-inflammatory response

Microplastics and Nanoplastics 2025 4 citations ? Citation count from OpenAlex, updated daily. May differ slightly from the publisher's own count.
Annemijne E. T. van den Berg, Kas J. Adriaans, Luke A. Parker, Elena M. Höppener, Hanna M. Dusza, Juliette Legler, Raymond Pieters

Summary

This study investigated whether top-down mechanically generated micro- and nanoplastics from physically shredded plastic affect macrophage viability and inflammation. The particles reduced macrophage viability in a dose-dependent manner but did not elicit a classical pro-inflammatory cytokine response.

Body Systems

The online version contains supplementary material available at 10.1186/s43591-025-00138-5.

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