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Probing the Cardiovascular Toxic Effects of Long-Term Exposure to Dibutyl Phthalate in Sprague-Dawley Rats Based on Oxidative Inflammation and Metabolic Pathways: Implications for the Heart and Blood Vessel
Summary
This study investigates the effects of prolonged microplastic exposure on cardiovascular health, examining how particles accumulate in cardiac tissues and disrupt normal function. Researchers documented toxic responses including inflammation, oxidative stress, and structural changes in heart and vascular tissue. The findings raise concern about the long-term cardiovascular risks posed by chronic microplastic exposure in humans and animals.
Long-term exposure to DBP can induce cardiovascular toxicity in rats, manifesting as cardiac and vascular damage, as well as alterations in organ function. This process is characterized by oxidative stress, activation of the pyroptosis pathway, inflammatory responses, and modifications to metabolic pathways.