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Probing the Cardiovascular Toxic Effects of Long-Term Exposure to Dibutyl Phthalate in Sprague-Dawley Rats Based on Oxidative Inflammation and Metabolic Pathways: Implications for the Heart and Blood Vessel
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This study investigates the effects of prolonged microplastic exposure on cardiovascular health, examining how particles accumulate in cardiac tissues and disrupt normal function. Researchers documented toxic responses including inflammation, oxidative stress, and structural changes in heart and vascular tissue. The findings raise concern about the long-term cardiovascular risks posed by chronic microplastic exposure in humans and animals.
Long-term exposure to DBP can induce cardiovascular toxicity in rats, manifesting as cardiac and vascular damage, as well as alterations in organ function. This process is characterized by oxidative stress, activation of the pyroptosis pathway, inflammatory responses, and modifications to metabolic pathways.
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Systemic investigation of di-isobutyl phthalate (DIBP) exposure in the risk of cardiovascular via influencing the gut microbiota arachidonic acid metabolism in obese mice model
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Researchers studied how di-isobutyl phthalate, a plasticizer chemical commonly found in food and water, affects cardiovascular health in both normal and obese mice. They found that the compound disrupted gut bacteria and altered fat metabolism pathways, with obese mice showing more severe effects including increased cardiovascular risk markers. The study suggests that exposure to this common plastic-related chemical may contribute to heart disease risk, particularly in people who are already overweight.
The cardiovascular toxicity of polystyrene microplastics in rats: based on untargeted metabolomics analysis
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A rat study using metabolomics analysis found that long-term exposure to high concentrations of polystyrene microplastics led to abnormal fat metabolism and cardiovascular damage. The harm appeared to be driven by oxidative stress and inflammation, suggesting that chronic microplastic exposure could contribute to heart and blood vessel disease.
Developmental toxicity and mechanism of dibutyl phthalate on the development of subintestinal vessels in zebrafish
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Researchers exposed zebrafish embryos to dibutyl phthalate (DBP), a common plastic plasticizer, and found it caused abnormal development of subintestinal blood vessels by increasing oxidative stress and disrupting the HIF signaling pathway. These findings provide mechanistic insight into how DBP interferes with vascular development during early life stages.
The Plasticizer Dibutyl Phthalate (DBP) Impairs Pregnancy Vascular Health: Insights into Calcium Signaling and Nitric Oxide Involvement
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Researchers investigated how the plasticizer dibutyl phthalate (DBP), found in household products and cosmetics, affects blood vessel function during pregnancy using human umbilical arteries. DBP induced concentration-dependent vasorelaxation through pathways involving nitric oxide signaling and calcium handling, suggesting it may alter arterial tone regulation and pose cardiovascular risks during pregnancy.
Long-term Effects of Polyethylene Terephthalate Nanoplastics on Heart Tissue in Male Wistar Rats
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Researchers studied the long-term effects of polyethylene terephthalate nanoplastics on heart tissue in male Wistar rats, finding histological changes and markers of oxidative stress after chronic exposure. The results suggest that nanoplastic accumulation may contribute to cardiac tissue damage over time.
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