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Article ? AI-assigned paper type based on the abstract. Classification may not be perfect — flag errors using the feedback button. Tier 2 ? Original research — experimental, observational, or case-control study. Direct primary evidence. Human Health Effects Nanoplastics Sign in to save

Micro‐ and Nanoplastic Toxicity in Upper Respiratory Tract: A Scoping Review

The Laryngoscope 2025
Jérôme R. Lechien, Mejdeddine Al Barajraji, Antonino Maniaci, Sophie Laurent, Samira Benali, Laurence Ris, Nicolas Massager, Jean‐Marie Raquez, Robin Baudouin, Stéphane Hans, Philippe Dubois, Mario Manto

Summary

This scoping review found that both exposed and unexposed humans have microplastics and nanoplastics detectable in nasal tissue and fluids, with mask wearing and old nasal lavage devices contributing to deposition, and experimental studies suggesting inflammatory tissue changes from upper respiratory tract NMP accumulation.

Body Systems
Respiratory

The current clinical and experimental studies demonstrate that both exposed and unexposed humans have nasal NMP detected in their nasal tissues and fluids. Mask wearing and the use of old plastic nasal lavage devices can contribute to this deposition. While experimental studies suggest changes in tissue and cell physiology, the toxicity of NMP in nasal tissue remains poorly investigated and has not been conclusively demonstrated.

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