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Inflammation mediation of the association between brominated flame retardants and psoriasis among U.S. adults
Summary
PBDE-153, a brominated flame retardant, was positively associated with psoriasis risk in U.S. adults, with inflammatory pathways partially mediating this relationship. Brominated flame retardants are commonly incorporated into plastic products and released as microplastics degrade, making this finding relevant to the broader health implications of plastic-associated chemical exposures.
This study suggests a positive association between PBDE153 exposure and psoriasis risk, with inflammatory pathways playing a partial mediating role. However, the cross-sectional design precludes causal inference. Therefore, longitudinal studies and experimental research are needed to establish such causal relationships.