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Conceptual Model Linking Night Shift Work, Circadian Disruption, and Microplastic Exposure as a Proxy Risk Indicator for Dementia
Summary
This paper proposes a conceptual framework linking night shift work, circadian rhythm disruption, and microplastic exposure as interconnected risk indicators for neurodegenerative conditions. The model does not claim microplastics are a direct cause but positions environmental microplastic burden as an exposure marker reflecting complex occupational and environmental risk pathways. The study aims to stimulate hypothesis-driven research into how these combined factors may relate to long-term brain health.
This manuscript proposes a conceptual framework integrating night shift work, circadian rhythm disruption, metabolic dysregulation, and microplastic exposure as a proxy marker for neurodegenerative risk. The model does not assert microplastics as a single causal factor but positions environmental microplastic burden as an exposure indicator reflecting complex environmental and occupational risk pathways. This work aims to stimulate hypothesis-driven research and interdisciplinary discussion in environmental health, occupational epidemiology, and neurodegenerative disease research.